---
res:
  bibo_abstract:
  - The origin(s) of life (OoL), which has puzzled scientists for centuries, remains
    a major scientific challenge in the 21st century. Understanding the processes
    relevant to the OoL demands theoretical frameworks that can connect processes
    across scales, from microscopic dynamics to emergent levels of organization. While
    experimental studies generate a wealth of data, theoretical and computational
    approaches provide the structure necessary to interpret and generalize these findings.
    In Part 1, we examined the most widely used experimental techniques in the field.
    Here, we focus on the mathematical, physical, and computational techniques used
    to model phenomena relevant to life’s origin(s). We discuss methods ranging from
    quantum chemistry and molecular dynamics to chemical reaction networks, autocatalysis,
    and evolutionary modeling, as well as information-theoretic and phylogenetic approaches
    that link chemical and biological organization. We further highlight emerging
    trends such as synthetic biology, omics-based methods, and laboratory automation
    as novel points of contact for theory-experiment integration. Ultimately, we aim
    to provide an educational tool that can facilitate more post-disciplinary collaborations
    in OoL research by helping scientists understand what they can do about the problem
    of life’s origins, rather than telling them how to think about it.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Silke
      foaf_name: Asche, Silke
      foaf_surname: Asche
  - foaf_Person:
      foaf_givenName: Carla
      foaf_name: Bautista, Carla
      foaf_surname: Bautista
  - foaf_Person:
      foaf_givenName: Celia
      foaf_name: Blanco, Celia
      foaf_surname: Blanco
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Boulesteix, David
      foaf_surname: Boulesteix
  - foaf_Person:
      foaf_givenName: Alexandre
      foaf_name: Champagne-Ruel, Alexandre
      foaf_surname: Champagne-Ruel
  - foaf_Person:
      foaf_givenName: Cole
      foaf_name: Mathis, Cole
      foaf_surname: Mathis
  - foaf_Person:
      foaf_givenName: Omer
      foaf_name: Markovitch, Omer
      foaf_surname: Markovitch
  - foaf_Person:
      foaf_givenName: Zhen
      foaf_name: Peng, Zhen
      foaf_surname: Peng
  - foaf_Person:
      foaf_givenName: Avinash Vicholous
      foaf_name: Dass, Avinash Vicholous
      foaf_surname: Dass
  - foaf_Person:
      foaf_givenName: Alyssa
      foaf_name: Adams, Alyssa
      foaf_surname: Adams
  - foaf_Person:
      foaf_givenName: Eloi
      foaf_name: Camprubi, Eloi
      foaf_surname: Camprubi
  - foaf_Person:
      foaf_givenName: Enrico Sandro
      foaf_name: Colizzi, Enrico Sandro
      foaf_surname: Colizzi
  - foaf_Person:
      foaf_givenName: Stephanie
      foaf_name: Colón-Santos, Stephanie
      foaf_surname: Colón-Santos
  - foaf_Person:
      foaf_givenName: Hannah
      foaf_name: Dromiack, Hannah
      foaf_surname: Dromiack
  - foaf_Person:
      foaf_givenName: Valentina
      foaf_name: Erastova, Valentina
      foaf_surname: Erastova
  - foaf_Person:
      foaf_givenName: Amanda
      foaf_name: Garcia, Amanda
      foaf_surname: Garcia
  - foaf_Person:
      foaf_givenName: Ghjuvan
      foaf_name: Grimaud, Ghjuvan
      foaf_surname: Grimaud
  - foaf_Person:
      foaf_givenName: Aaron
      foaf_name: Halpern, Aaron
      foaf_surname: Halpern
  - foaf_Person:
      foaf_givenName: Stuart A.
      foaf_name: Harrison, Stuart A.
      foaf_surname: Harrison
  - foaf_Person:
      foaf_givenName: Seán F.
      foaf_name: Jordan, Seán F.
      foaf_surname: Jordan
  - foaf_Person:
      foaf_givenName: Tony Z.
      foaf_name: Jia, Tony Z.
      foaf_surname: Jia
  - foaf_Person:
      foaf_givenName: Amit
      foaf_name: Kahana, Amit
      foaf_surname: Kahana
  - foaf_Person:
      foaf_givenName: Artemy
      foaf_name: Kolchinsky, Artemy
      foaf_surname: Kolchinsky
  - foaf_Person:
      foaf_givenName: Odin
      foaf_name: Moron-Garcia, Odin
      foaf_surname: Moron-Garcia
  - foaf_Person:
      foaf_givenName: Ryo
      foaf_name: Mizuuchi, Ryo
      foaf_surname: Mizuuchi
  - foaf_Person:
      foaf_givenName: Jingbo
      foaf_name: Nan, Jingbo
      foaf_surname: 'Nan'
  - foaf_Person:
      foaf_givenName: Yuliia
      foaf_name: Orlova, Yuliia
      foaf_surname: Orlova
  - foaf_Person:
      foaf_givenName: Ben K.D.
      foaf_name: Pearce, Ben K.D.
      foaf_surname: Pearce
  - foaf_Person:
      foaf_givenName: Klaus
      foaf_name: Paschek, Klaus
      foaf_surname: Paschek
  - foaf_Person:
      foaf_givenName: Martina
      foaf_name: Preiner, Martina
      foaf_surname: Preiner
  - foaf_Person:
      foaf_givenName: Silvana
      foaf_name: Pinna, Silvana
      foaf_surname: Pinna
  - foaf_Person:
      foaf_givenName: Eduardo
      foaf_name: Rodríguez-Román, Eduardo
      foaf_surname: Rodríguez-Román
  - foaf_Person:
      foaf_givenName: Loraine
      foaf_name: Schwander, Loraine
      foaf_surname: Schwander
  - foaf_Person:
      foaf_givenName: Siddhant
      foaf_name: Sharma, Siddhant
      foaf_surname: Sharma
      foaf_workInfoHomepage: http://www.librecat.org/personId=36996868-4916-11f1-8c9d-c0c901467b61
  - foaf_Person:
      foaf_givenName: Harrison B.
      foaf_name: Smith, Harrison B.
      foaf_surname: Smith
  - foaf_Person:
      foaf_givenName: Andrey
      foaf_name: Vieira, Andrey
      foaf_surname: Vieira
  - foaf_Person:
      foaf_givenName: Joana C.
      foaf_name: Xavier, Joana C.
      foaf_surname: Xavier
  bibo_doi: 10.1016/j.xcrp.2026.103211
  bibo_issue: '4'
  bibo_volume: 7
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2666-3864
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: 'What it takes to solve the origins of life: An integrated review. Part
    2: Theoretical methods and emerging trends@'
...