---
res:
  bibo_abstract:
  - Neural tube closure is a critical morphogenetic process in vertebrate development,
    and failure to close cranial regions such as the hindbrain neuropore (HNP) leads
    to severe congenital malformations. While mechanical forces such as actomyosin
    purse-string contraction and directional cell crawling have been implicated in
    driving HNP closure, how these forces organize local cell shape and motion to
    produce large-scale tissue remodeling remains poorly understood. Using live and
    fixed imaging of mouse embryos combined with cell-based biophysical modeling,
    we show that these force-generating mechanisms are insufficient to explain the
    reproducible patterns of cell elongation and nematic alignment observed at the
    HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization
    are required to generate these patterns and promote midline cell motion. Our model
    captures key features of cell shape dynamics and emergent nematic order, which
    we confirm experimentally, including the alignment of actin fibers with cell shape
    and enhanced midline cell speed. Comparative analysis with chick embryos, which
    lack supracellular purse strings, supports a conserved link between tension generation
    and cellular patterning. These findings establish a physical framework connecting
    force generation, cell shape anisotropy, and tissue morphodynamics during epithelial
    gap closure.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Fernanda L
      foaf_name: Perez Verdugo, Fernanda L
      foaf_surname: Perez Verdugo
      foaf_workInfoHomepage: http://www.librecat.org/personId=4ecec223-9070-11ef-a0a9-bc76077bea8d
  - foaf_Person:
      foaf_givenName: Eirini
      foaf_name: Maniou, Eirini
      foaf_surname: Maniou
  - foaf_Person:
      foaf_givenName: Gabriel L.
      foaf_name: Galea, Gabriel L.
      foaf_surname: Galea
  - foaf_Person:
      foaf_givenName: Shiladitya
      foaf_name: Banerjee, Shiladitya
      foaf_surname: Banerjee
  bibo_doi: 10.1016/j.cub.2026.02.068
  bibo_issue: '8'
  bibo_volume: 36
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0960-9822
  - http://id.crossref.org/issn/1879-0445
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Mechanosensitive feedback organizes cell shape and motion during hindbrain
    neuropore morphogenesis@
  fabio_hasPubmedId: '41881011'
...