---
res:
  bibo_abstract:
  - The advantageous characteristics attributed to the 19F nucleus have made it a
    popular target for nuclear magnetic resonance (NMR) once again in recent years.
    Aside from solution NMR, an increasing number of studies have been conducted applying
    solid-state magic-angle spinning (MAS) NMR to fluorine-labelled samples. Here,
    the high chemical shift anisotropy and strong dipolar couplings can be utilised
    to get structural insights into proteins and measure long distances. Despite increasing
    popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR
    often suffers from slow longitudinal T1 relaxation and therefore long recycle
    delays. In this work, we expand paramagnetic doping, an approach commonly used
    to reduce proton T1 relaxation times, to 19F-labelled biological samples. We study
    the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F T1 and T2, and 13C T1 and T2 relaxation
    in a [5-19F13C]-tryptophan-labelled protein via 19F-detected MAS NMR experiments.
    The observed paramagnetic relaxation enhancement substantially reduces measurement
    times of 19F MAS NMR experiments without compromising resolution. Additionally,
    we report the chemical shift assignments of all four fluorotryptophan signals
    in the 12×39 kDa-large protein TET2 using a mutagenesis approach.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Lea Marie
      foaf_name: Becker, Lea Marie
      foaf_surname: Becker
      foaf_workInfoHomepage: http://www.librecat.org/personId=36336939-eb97-11eb-a6c2-c83f1214ca79
    orcid: 0000-0002-6401-5151
  - foaf_Person:
      foaf_givenName: Giorgia
      foaf_name: Toscano, Giorgia
      foaf_surname: Toscano
      foaf_workInfoHomepage: http://www.librecat.org/personId=334a5e40-8747-11f0-b671-ba1f5154b4b4
  - foaf_Person:
      foaf_givenName: Anna
      foaf_name: Kapitonova, Anna
      foaf_surname: Kapitonova
      foaf_workInfoHomepage: http://www.librecat.org/personId=9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
  - foaf_Person:
      foaf_givenName: Rajkumar
      foaf_name: Singh, Rajkumar
      foaf_surname: Singh
      foaf_workInfoHomepage: http://www.librecat.org/personId=a3089acd-6806-11ee-bacc-f0c7d500ad20
  - foaf_Person:
      foaf_givenName: Undina
      foaf_name: Guillerm, Undina
      foaf_surname: Guillerm
      foaf_workInfoHomepage: http://www.librecat.org/personId=bb74f472-ae54-11eb-9835-bc9c22fb1183
  - foaf_Person:
      foaf_givenName: Roman J.
      foaf_name: Lichtenecker, Roman J.
      foaf_surname: Lichtenecker
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Schanda, Paul
      foaf_surname: Schanda
      foaf_workInfoHomepage: http://www.librecat.org/personId=7B541462-FAF6-11E9-A490-E8DFE5697425
    orcid: 0000-0002-9350-7606
  bibo_doi: 10.5194/mr-7-29-2026
  bibo_issue: '1'
  bibo_volume: 7
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2699-0016
  dct_language: eng
  dct_publisher: Copernicus Publications@
  dct_title: Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic
    dopants@
  fabio_hasPubmedId: '42057802'
...