Facile access to foldable redox-active flavin-peptide conjugates

article Facile access to foldable redox-active flavin-peptide conjugates published yes Friedrich J Stricker author 7aca2cfc-46cf-11f0-abd3-8c96b5186745 Jonas Christopher Kölsch author Sebastian B. Beil author Sebastian Preiß author Siegfried R. Waldvogel author Till Opatz author Pol Besenius author A convenient approach for the synthesis of foldable redox-active flavin peptide conjugates was established. A model β-hairpin oligopeptide motif was utilized to demonstrate that azidolysine side-chains are readily functionalised with an alkyne-bearing flavine derivative. The folding equilibrium of the peptide backbone as well as the redox behaviour of the flavin moieties remains intact after the conjugation. Royal Society of Chemistry2021 eng Organic & Biomolecular Chemistry 1477-0520 1477-0539 3396099710.1039/d1ob00414j 19204483-4486 yes F.J. Stricker, J.C. Kölsch, S.B. Beil, S. Preiß, S.R. Waldvogel, T. Opatz, P. Besenius, Organic & Biomolecular Chemistry 19 (2021) 4483–4486. Stricker FJ, Kölsch JC, Beil SB, Preiß S, Waldvogel SR, Opatz T, Besenius P. 2021. Facile access to foldable redox-active flavin-peptide conjugates. Organic & Biomolecular Chemistry. 19(20), 4483–4486. F. J. Stricker et al., “Facile access to foldable redox-active flavin-peptide conjugates,” Organic & Biomolecular Chemistry, vol. 19, no. 20. Royal Society of Chemistry, pp. 4483–4486, 2021. Stricker, Friedrich J., et al. “Facile Access to Foldable Redox-Active Flavin-Peptide Conjugates.” Organic & Biomolecular Chemistry, vol. 19, no. 20, Royal Society of Chemistry, 2021, pp. 4483–86, doi:<a href="https://doi.org/10.1039/d1ob00414j">10.1039/d1ob00414j</a>. Stricker, F. J., Kölsch, J. C., Beil, S. B., Preiß, S., Waldvogel, S. R., Opatz, T., & Besenius, P. (2021). Facile access to foldable redox-active flavin-peptide conjugates. Organic & Biomolecular Chemistry. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d1ob00414j">https://doi.org/10.1039/d1ob00414j</a> Stricker FJ, Kölsch JC, Beil SB, et al. Facile access to foldable redox-active flavin-peptide conjugates. Organic & Biomolecular Chemistry. 2021;19(20):4483-4486. doi:<a href="https://doi.org/10.1039/d1ob00414j">10.1039/d1ob00414j</a> Stricker, Friedrich J, Jonas Christopher Kölsch, Sebastian B. Beil, Sebastian Preiß, Siegfried R. Waldvogel, Till Opatz, and Pol Besenius. “Facile Access to Foldable Redox-Active Flavin-Peptide Conjugates.” Organic & Biomolecular Chemistry. Royal Society of Chemistry, 2021. <a href="https://doi.org/10.1039/d1ob00414j">https://doi.org/10.1039/d1ob00414j</a>. 218082026-05-06T10:44:41Z2026-05-11T07:34:17Z