---
res:
  bibo_abstract:
  - "Background & Aims: To develop and validate a CT-based radiomics model to assess
    HVPG and predict a composite endpoint of liver-related events (LRE: decompensation
    and liver-related death) in patients with cirrhosis.\r\n\r\nMethods: This retrospective
    study included 357 cirrhosis patients, who received invasive HVPG measurements,
    120 liver-healthy controls (training cohort) and 85 and 100 cirrhosis patients
    (internal and external validation cohorts, respectively), and contrast-enhanced
    abdominal CTs. After volumetric segmentation of the liver and spleen on CT, Bayesian
    parameter optimization was used for selection of extracted features and hyperparameter
    tuning in random forest or elastic net models. Prediction accuracy was evaluated
    using Pearson correlation coefficients of predicted (’radio-HVPG’) and invasive
    HVPG. Discrimination between relevant HVPG cut-offs was determined by receiver
    operating characteristic (ROC) analysis. The predictive value of radio-HVPG and
    invasive-HVPG for LRE was compared using Cox regression models.\r\n\r\nResults:
    Radio-HVPG, predicted by an optimized random forest model based on 74 selected
    CT features, correlated with invasive-HVPG and detected clinically significant
    portal hypertension (CSPH: HVPG ≥ 10 mmHg) on the internal (Pearson r = 0.63,
    AUC 0.89 [95% CI: 0.81–0.96]) and external (Pearson r = 0.62, AUC 0.80 [95% CI:
    0.64–0.91]) validation cohorts. Radio-HVPG predicted LRE when adjusting for MELD
    and albumin (adjusted HR: 1.14 [95% CI: 1.04–1.25], p = 0.005) and performed similarly
    to invasive-HVPG.\r\n\r\nConclusions: Radiomic features accurately predict HVPG
    in patients with cirrhosis and allow risk stratification for LRE in a radiomics-clinical
    signature.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Celine
      foaf_name: Sin, Celine
      foaf_surname: Sin
  - foaf_Person:
      foaf_givenName: Martin Luther
      foaf_name: Watzenboeck, Martin Luther
      foaf_surname: Watzenboeck
  - foaf_Person:
      foaf_givenName: Eugenia B
      foaf_name: Iofinova, Eugenia B
      foaf_surname: Iofinova
      foaf_workInfoHomepage: http://www.librecat.org/personId=f9a17499-f6e0-11ea-865d-fdf9a3f77117
    orcid: 0000-0002-7778-3221
  - foaf_Person:
      foaf_givenName: Lorenz
      foaf_name: Balcar, Lorenz
      foaf_surname: Balcar
  - foaf_Person:
      foaf_givenName: Georg
      foaf_name: Semmler, Georg
      foaf_surname: Semmler
  - foaf_Person:
      foaf_givenName: Bernhard
      foaf_name: Scheiner, Bernhard
      foaf_surname: Scheiner
  - foaf_Person:
      foaf_givenName: Katharina
      foaf_name: Lampichler, Katharina
      foaf_surname: Lampichler
  - foaf_Person:
      foaf_givenName: Mattias
      foaf_name: Mandorfer, Mattias
      foaf_surname: Mandorfer
  - foaf_Person:
      foaf_givenName: Lucile
      foaf_name: Moga, Lucile
      foaf_surname: Moga
  - foaf_Person:
      foaf_givenName: Pierre‐Emmanuel
      foaf_name: Rautou, Pierre‐Emmanuel
      foaf_surname: Rautou
  - foaf_Person:
      foaf_givenName: Maxime
      foaf_name: Ronot, Maxime
      foaf_surname: Ronot
  - foaf_Person:
      foaf_givenName: Jörg
      foaf_name: Menche, Jörg
      foaf_surname: Menche
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Reiberger, Thomas
      foaf_surname: Reiberger
  - foaf_Person:
      foaf_givenName: Martina
      foaf_name: Scharitzer, Martina
      foaf_surname: Scharitzer
  bibo_doi: 10.1111/liv.70633
  bibo_issue: '5'
  bibo_volume: 46
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1478-3223
  - http://id.crossref.org/issn/1478-3231
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - computed tomography
  - liver
  - portal hypertension
  - radiomics
  - spleen
  dct_title: Radiomics‐based assessment of portal hypertension severity and risk stratification
    of cirrhotic patients using routine CT scans@
  fabio_hasPubmedId: '41943460'
...