---
res:
  bibo_abstract:
  - The long-standing notion that genotypes map to phenotypes through simple one gene–one
    trait relationships continues to shape both research in the life sciences and
    public understanding, with implications for policy and funding priorities. Yet
    this paradigm is increasingly recognized as inadequate for explaining continuous
    phenotypic variation and the complex genetic architectures of the genotype–phenotype
    map. Modern genetics emerged from the early 20th-century synthesis of Mendelian
    and biometric schools of heredity, with R.A. Fisher demonstrating early on how
    multiple discrete loci could collectively produce continuous variation. Despite
    this fundamental insight, Mendelism—with its focus on single genes and standardized
    genetic backgrounds—became the dominant framework, shaping current genetics research
    and molecular biology as well as science education. The advent of large-scale
    genomic data has revealed yet again the limitations of this reductionist approach.
    Evidence from quantitative genetics now shows that most phenotypes arise from
    complex networks of many interdependent genes and their dynamic responses to environmental
    perturbations. Here we trace the historical roots of how Mendelian classical genetics
    departed from the biometric school to create the current predominant paradigm
    in genetics, despite fundamentally unresolved issues. Moving on from this one-sided
    paradigm will require systematic development of integrative, evolutionarily grounded
    experimental approaches that better capture the multigenic and context-dependent
    nature of inheritance. Achieving such an extended perspective will require methodological
    innovation, including advances in large-scale (e.g. automated) phenotyping. Dedicated
    research programs will be necessary to advance a new era of genetic research into
    the complex mechanisms underlying phenotypic variation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Diethard
      foaf_name: Tautz, Diethard
      foaf_surname: Tautz
  - foaf_Person:
      foaf_givenName: Luisa F
      foaf_name: Pallares, Luisa F
      foaf_surname: Pallares
  - foaf_Person:
      foaf_givenName: Leif
      foaf_name: Andersson, Leif
      foaf_surname: Andersson
  - foaf_Person:
      foaf_givenName: Neda
      foaf_name: Barghi, Neda
      foaf_surname: Barghi
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  - foaf_Person:
      foaf_givenName: Rachael
      foaf_name: Bay, Rachael
      foaf_surname: Bay
  - foaf_Person:
      foaf_givenName: Yingguang Frank
      foaf_name: Chan, Yingguang Frank
      foaf_surname: Chan
  - foaf_Person:
      foaf_givenName: Angela
      foaf_name: Hancock, Angela
      foaf_surname: Hancock
  - foaf_Person:
      foaf_givenName: Tobias S
      foaf_name: Kaiser, Tobias S
      foaf_surname: Kaiser
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Koenig, Daniel
      foaf_surname: Koenig
  - foaf_Person:
      foaf_givenName: Zacharias
      foaf_name: Kontarakis, Zacharias
      foaf_surname: Kontarakis
  - foaf_Person:
      foaf_givenName: Miriam
      foaf_name: Liedvogel, Miriam
      foaf_surname: Liedvogel
  - foaf_Person:
      foaf_givenName: Juliette
      foaf_name: de Meaux, Juliette
      foaf_surname: de Meaux
  - foaf_Person:
      foaf_givenName: Magnus
      foaf_name: Nordborg, Magnus
      foaf_surname: Nordborg
  - foaf_Person:
      foaf_givenName: Abraham A
      foaf_name: Palmer, Abraham A
      foaf_surname: Palmer
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Purugganan, Michael
      foaf_surname: Purugganan
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Schlötterer, Christian
      foaf_surname: Schlötterer
  - foaf_Person:
      foaf_givenName: Karl
      foaf_name: Schmid, Karl
      foaf_surname: Schmid
  - foaf_Person:
      foaf_givenName: Didier Y R
      foaf_name: Stainier, Didier Y R
      foaf_surname: Stainier
  - foaf_Person:
      foaf_givenName: Detlef
      foaf_name: Weigel, Detlef
      foaf_surname: Weigel
  - foaf_Person:
      foaf_givenName: Jochen B W
      foaf_name: Wolf, Jochen B W
      foaf_surname: Wolf
  - foaf_Person:
      foaf_givenName: Dieter
      foaf_name: Ebert, Dieter
      foaf_surname: Ebert
  - foaf_Person:
      foaf_givenName: Greg
      foaf_name: Gibson, Greg
      foaf_surname: Gibson
  bibo_doi: 10.1093/genetics/iyag024
  bibo_issue: '4'
  bibo_volume: 232
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1943-2631
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_subject:
  - classic genetics
  - quantitative genetics
  - genotype–phenotype map
  dct_title: 'Beyond Mendel: A call to revisit the genotype–phenotype map through
    new experimental paradigms@'
  fabio_hasPubmedId: '41701356'
...