---
res:
  bibo_abstract:
  - 'Despite the success of mRNA therapeutics, challenges remain in optimizing immune
    responses and minimizing side effects. Cell-specific antigen delivery may help
    reduce required doses and improve vaccine efficacy. In this study, we report on
    a targeted delivery system for mRNA to a specific subset of skin-resident antigen-presenting
    cells: Langerhans cells. By functionalizing lipid nanoparticles with a langerin-specific
    glycomimetic ligand, we achieve selective mRNA delivery to both murine and human
    primary Langerhans cells with minimal off-target uptake, at the same time resulting
    in significantly increased mRNA translation. This targeted mRNA delivery not only
    enhances antigen presentation and T-cell responses but also enables dose-sparing
    and superior antitumor immunity compared with conventional immunization in a B16-OVA
    tumor model. Importantly, our platform’s high compatibility with various lipid
    nanoparticle formulations offers a flexible and precise tool for skin-directed
    mRNA delivery.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Klara
      foaf_name: Klein, Klara
      foaf_surname: Klein
  - foaf_Person:
      foaf_givenName: Litty
      foaf_name: Johnson, Litty
      foaf_surname: Johnson
  - foaf_Person:
      foaf_givenName: Ramona
      foaf_name: Rîca, Ramona
      foaf_surname: Rîca
  - foaf_Person:
      foaf_givenName: Mirza
      foaf_name: Sarcevic, Mirza
      foaf_surname: Sarcevic
  - foaf_Person:
      foaf_givenName: Gabriele
      foaf_name: Carta, Gabriele
      foaf_surname: Carta
  - foaf_Person:
      foaf_givenName: Saskia
      foaf_name: Seiser, Saskia
      foaf_surname: Seiser
  - foaf_Person:
      foaf_givenName: Adelheid
      foaf_name: Elbe-Bürger, Adelheid
      foaf_surname: Elbe-Bürger
  - foaf_Person:
      foaf_givenName: Freyja
      foaf_name: Langer, Freyja
      foaf_surname: Langer
      foaf_workInfoHomepage: http://www.librecat.org/personId=3C1BE782-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Nowras
      foaf_name: Rahhal, Nowras
      foaf_surname: Rahhal
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Rademacher, Christoph
      foaf_surname: Rademacher
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Wawrzinek, Robert
      foaf_surname: Wawrzinek
  - foaf_Person:
      foaf_givenName: Federica
      foaf_name: Quattrone, Federica
      foaf_surname: Quattrone
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Sparber, Florian
      foaf_surname: Sparber
  bibo_doi: 10.1016/j.jid.2026.03.026
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0022-202X
  - http://id.crossref.org/issn/1523-1747
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: 'Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing
    and enhanced antitumor immunity@'
...