---
res:
  bibo_abstract:
  - The development of complex tissues relies on the precise assignment of cell identity.
    At the molecular scale, this process depends on the deposition of epigenetic modifications—such
    as methylation—that are regulated by complex biochemical networks and occur at
    specific regions on the DNA and chromatin. Here we show that despite the complexity
    of epigenetic regulation, dynamical scaling and self-similarity of DNA methylation
    marks emerge in embryonic development. Drawing on single-cell multi-omics experiments,
    super-resolution microscopy and statistical physics, we demonstrate that these
    phenomena originate in dynamical feedback between DNA methylation and the formation
    of nanoscale dynamic chromatin aggregates. These nanoscale processes lead to genome-wide
    increase in DNA methylation marks following a power law and self-similar correlation
    functions. Using this framework, we identify methylation patterns that precede
    gene expression changes in embryonic symmetry breaking. Our work identifies linear
    sequencing measurements as a laboratory to study mesoscopic biophysical processes
    in vivo.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Fabrizio
      foaf_name: Olmeda, Fabrizio
      foaf_surname: Olmeda
      foaf_workInfoHomepage: http://www.librecat.org/personId=69dbf5fb-8a76-11ed-866b-fb486d8b5689
  - foaf_Person:
      foaf_givenName: Tim
      foaf_name: Lohoff, Tim
      foaf_surname: Lohoff
  - foaf_Person:
      foaf_givenName: Ioannis
      foaf_name: Kafetzopoulos, Ioannis
      foaf_surname: Kafetzopoulos
  - foaf_Person:
      foaf_givenName: Stephen J.
      foaf_name: Clark, Stephen J.
      foaf_surname: Clark
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Benson, Laura
      foaf_surname: Benson
  - foaf_Person:
      foaf_givenName: Fatima
      foaf_name: Santos, Fatima
      foaf_surname: Santos
  - foaf_Person:
      foaf_givenName: Felix
      foaf_name: Krueger, Felix
      foaf_surname: Krueger
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Walker, Simon
      foaf_surname: Walker
  - foaf_Person:
      foaf_givenName: Wolf
      foaf_name: Reik, Wolf
      foaf_surname: Reik
  - foaf_Person:
      foaf_givenName: Steffen
      foaf_name: Rulands, Steffen
      foaf_surname: Rulands
  bibo_doi: 10.1038/s41567-026-03263-x
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1745-2473
  - http://id.crossref.org/issn/1745-2481
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Scaling and self-similarity in the formation of the embryonic epigenome@
...