---
res:
  bibo_abstract:
  - 'Cyclic adenosine monophosphate (cAMP) is a fundamental second messenger involved
    in diverse signaling pathways across both animals and plants. While the role of
    3′,5′-cAMP has been extensively characterized, the biological significance of
    its structural isomer, 2′,3′-cAMP, remains largely unexplored, particularly in
    plants. Here, we show that 2′,3′-cAMP and 3′,5′-cAMP represent parallel signaling
    systems in Arabidopsis thaliana, with different enzymatic origins and largely
    distinct downstream effects. In vitro enzymatic assays show that plant adenylate
    cyclases (ACs), including AFB5 and HpAC1, produce specifically 3′,5′-cAMP from
    ATP, whereas the TIR domain of protein L7 also catalyzes the formation of 2′,3′-cAMP
    from RNA. Comprehensive multiomics analyses reveal that two isomers elicit distinct
    yet partially overlapping metabolic, proteomic, and transcriptional response:
    2′,3′-cAMP activates broad, stress-adaptive gene expression reprogramming, while
    3′,5′-cAMP fine-tunes responses related to nutrient status and cellular homeostasis.
    Our findings establish the existence of dual cAMP signaling systems in plants,
    each with specialized functions and provide insights into the complex regulatory
    networks governing plant physiology.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Mingyue
      foaf_name: Li, Mingyue
      foaf_surname: Li
      foaf_workInfoHomepage: http://www.librecat.org/personId=01f96916-0235-11eb-9379-a323192643b7
  - foaf_Person:
      foaf_givenName: Monika
      foaf_name: Chodasiewicz, Monika
      foaf_surname: Chodasiewicz
  - foaf_Person:
      foaf_givenName: Malavika
      foaf_name: Muraleedharan, Malavika
      foaf_surname: Muraleedharan
  - foaf_Person:
      foaf_givenName: Israel M.
      foaf_name: Lopez, Israel M.
      foaf_surname: Lopez
  - foaf_Person:
      foaf_givenName: Michal
      foaf_name: Gorka, Michal
      foaf_surname: Gorka
  - foaf_Person:
      foaf_givenName: Olga
      foaf_name: Kerber, Olga
      foaf_surname: Kerber
  - foaf_Person:
      foaf_givenName: Saqer S.
      foaf_name: Alotaibi, Saqer S.
      foaf_surname: Alotaibi
  - foaf_Person:
      foaf_givenName: Andrew D.L.
      foaf_name: Nelson, Andrew D.L.
      foaf_surname: Nelson
  - foaf_Person:
      foaf_givenName: Rene
      foaf_name: Lenobel, Rene
      foaf_surname: Lenobel
  - foaf_Person:
      foaf_givenName: Jaroslava
      foaf_name: Friedecká, Jaroslava
      foaf_surname: Friedecká
  - foaf_Person:
      foaf_givenName: Aleksandra
      foaf_name: Skirycz, Aleksandra
      foaf_surname: Skirycz
  - foaf_Person:
      foaf_givenName: Jiří
      foaf_name: Friml, Jiří
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  bibo_doi: 10.1126/sciadv.aea7828
  bibo_issue: '19'
  bibo_volume: 12
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2375-2548
  dct_language: eng
  dct_publisher: AAAS@
  dct_title: Biogenesis and downstream effects of 3',5' and 2',3' cAMP isomers in
    plants@
  fabio_hasPubmedId: '42102187'
...