---
res:
  bibo_abstract:
  - Antibiotic combination in time and space is a key strategy to combat antimicrobial
    resistance. The success of such treatment designs requires their robust efficacy
    across treatment conditions and a pathogen’s genomic diversity. This study found
    that an initial treatment with a β-lactam antibiotic causes robust cellular sensitization
    towards an aminoglycoside antibiotic across the high-risk human pathogen Pseudomonas
    aeruginosa, including resistant strains. This phenomenon of cellular sensitization,
    termed negative hysteresis, is modulated by the Cpx envelope stress response system
    and linked to membrane stress during growth. The increase in efficacy is achieved
    through a β-lactam induced elevated cellular uptake of the subsequently administered
    aminoglycoside. Negative hysteresis and the Cpx system are linked in several cases
    to the expression of synergistic drug interactions, thus enhancing efficacy of
    antibiotic combinations. Overall, our study identifies the phenomenon of negative
    hysteresis as a robustly inducible phenotype and thus a unique focus for optimizing
    antimicrobial therapy.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Buchholz, Florian
      foaf_surname: Buchholz
  - foaf_Person:
      foaf_givenName: Lina M.
      foaf_name: Upterworth, Lina M.
      foaf_surname: Upterworth
  - foaf_Person:
      foaf_givenName: Leif
      foaf_name: Tueffers, Leif
      foaf_surname: Tueffers
  - foaf_Person:
      foaf_givenName: Espen E.
      foaf_name: Groth, Espen E.
      foaf_surname: Groth
  - foaf_Person:
      foaf_givenName: Kira
      foaf_name: Haas, Kira
      foaf_surname: Haas
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Schütz, Daniel
      foaf_surname: Schütz
  - foaf_Person:
      foaf_givenName: Abigail
      foaf_name: Savietto Scholz, Abigail
      foaf_surname: Savietto Scholz
  - foaf_Person:
      foaf_givenName: Aditi
      foaf_name: Batra, Aditi
      foaf_surname: Batra
  - foaf_Person:
      foaf_givenName: Surajit
      foaf_name: Pal, Surajit
      foaf_surname: Pal
  - foaf_Person:
      foaf_givenName: Samarpita
      foaf_name: Banerjee, Samarpita
      foaf_surname: Banerjee
  - foaf_Person:
      foaf_givenName: Badri N.
      foaf_name: Dubey, Badri N.
      foaf_surname: Dubey
  - foaf_Person:
      foaf_givenName: Sören
      foaf_name: Franzenburg, Sören
      foaf_surname: Franzenburg
  - foaf_Person:
      foaf_givenName: Barbara
      foaf_name: Kalsdorf, Barbara
      foaf_surname: Kalsdorf
  - foaf_Person:
      foaf_givenName: Klaus F.
      foaf_name: Rabe, Klaus F.
      foaf_surname: Rabe
  - foaf_Person:
      foaf_givenName: Dennis
      foaf_name: Nurjadi, Dennis
      foaf_surname: Nurjadi
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Rupp, Jan
      foaf_surname: Rupp
  - foaf_Person:
      foaf_givenName: Dan I.
      foaf_name: Andersson, Dan I.
      foaf_surname: Andersson
  - foaf_Person:
      foaf_givenName: Holger
      foaf_name: Sondermann, Holger
      foaf_surname: Sondermann
  - foaf_Person:
      foaf_givenName: Marc
      foaf_name: Bramkamp, Marc
      foaf_surname: Bramkamp
  - foaf_Person:
      foaf_givenName: Roderich
      foaf_name: Römhild, Roderich
      foaf_surname: Römhild
      foaf_workInfoHomepage: http://www.librecat.org/personId=68E56E44-62B0-11EA-B963-444F3DDC885E
    orcid: 0000-0001-9480-5261
  - foaf_Person:
      foaf_givenName: Hinrich
      foaf_name: Schulenburg, Hinrich
      foaf_surname: Schulenburg
  bibo_doi: 10.1038/s41467-026-71178-5
  bibo_volume: 17
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa
    via negative hysteresis in the cell envelope@
...