---
res:
  bibo_abstract:
  - 'The import of proteins into mitochondria poses fundamental mechanistic challenges:
    aggregation-prone precursor proteins must be maintained in aqueous compartments
    and threaded through narrow pores without becoming stuck or mislocalized. Recent
    evidence from mitochondrial protein import studies and other chaperone systems
    underscores the critical role of dynamics in balancing sufficiently tight binding,
    promiscuity, specificity, and release. Dynamic binding of client precursor proteins
    to import machinery components arises naturally from the avidity of their interactions.
    Conformational entropy enhances their stability, while the multivalent nature
    of these interactions ensures that client transfer to downstream insertases occurs
    without a substantial energy barrier. Here, we discuss this emerging paradigm
    of dynamic protein handling, using examples where dynamic structures have been
    resolved and highlight outstanding questions.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jakob
      foaf_name: Schneider, Jakob
      foaf_surname: Schneider
      foaf_workInfoHomepage: http://www.librecat.org/personId=64368429-eb97-11eb-a6c2-c980b1f44415
  - foaf_Person:
      foaf_givenName: Undina
      foaf_name: Guillerm, Undina
      foaf_surname: Guillerm
      foaf_workInfoHomepage: http://www.librecat.org/personId=bb74f472-ae54-11eb-9835-bc9c22fb1183
  - foaf_Person:
      foaf_givenName: Caroline
      foaf_name: Simoes Pereira, Caroline
      foaf_surname: Simoes Pereira
      foaf_workInfoHomepage: http://www.librecat.org/personId=87266c4a-96d2-11ef-be2c-fe5633233ec3
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Schanda, Paul
      foaf_surname: Schanda
      foaf_workInfoHomepage: http://www.librecat.org/personId=7B541462-FAF6-11E9-A490-E8DFE5697425
    orcid: 0000-0002-9350-7606
  bibo_doi: 10.1002/pro.70630
  bibo_issue: '6'
  bibo_volume: 35
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0961-8368
  - http://id.crossref.org/issn/1469-896X
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: Dynamic disorder is crucial for mitochondrial protein import@
  fabio_hasPubmedId: '42159315'
...