[{"intvolume":"        35","type":"journal_article","status":"public","day":"01","article_number":"e70630","date_published":"2026-06-01T00:00:00Z","acknowledgement":"We gratefully acknowledge research funding by the Austrian Science Fund (FWF), projects 10.55776/PAT1647625 and 10.55776/I6223. We thank Prof. Long Li (Peking University) for providing structural models and EM density for the TOM and TIM23 complexes, used to generate part of Figure 3. Open Access funding provided by Institute of Science and Technology Austria.","citation":{"apa":"Schneider, J., Guillerm, U., Simoes Pereira, C., &#38; Schanda, P. (2026). Dynamic disorder is crucial for mitochondrial protein import. <i>Protein Science</i>. Wiley. <a href=\"https://doi.org/10.1002/pro.70630\">https://doi.org/10.1002/pro.70630</a>","ista":"Schneider J, Guillerm U, Simoes Pereira C, Schanda P. 2026. Dynamic disorder is crucial for mitochondrial protein import. Protein Science. 35(6), e70630.","ama":"Schneider J, Guillerm U, Simoes Pereira C, Schanda P. Dynamic disorder is crucial for mitochondrial protein import. <i>Protein Science</i>. 2026;35(6). doi:<a href=\"https://doi.org/10.1002/pro.70630\">10.1002/pro.70630</a>","ieee":"J. Schneider, U. Guillerm, C. Simoes Pereira, and P. Schanda, “Dynamic disorder is crucial for mitochondrial protein import,” <i>Protein Science</i>, vol. 35, no. 6. Wiley, 2026.","chicago":"Schneider, Jakob, Undina Guillerm, Caroline Simoes Pereira, and Paul Schanda. “Dynamic Disorder Is Crucial for Mitochondrial Protein Import.” <i>Protein Science</i>. Wiley, 2026. <a href=\"https://doi.org/10.1002/pro.70630\">https://doi.org/10.1002/pro.70630</a>.","mla":"Schneider, Jakob, et al. “Dynamic Disorder Is Crucial for Mitochondrial Protein Import.” <i>Protein Science</i>, vol. 35, no. 6, e70630, Wiley, 2026, doi:<a href=\"https://doi.org/10.1002/pro.70630\">10.1002/pro.70630</a>.","short":"J. Schneider, U. Guillerm, C. Simoes Pereira, P. Schanda, Protein Science 35 (2026)."},"pmid":1,"department":[{"_id":"GradSch"},{"_id":"PaSc"}],"ddc":["572"],"abstract":[{"text":"The import of proteins into mitochondria poses fundamental mechanistic challenges: aggregation-prone precursor proteins must be maintained in aqueous compartments and threaded through narrow pores without becoming stuck or mislocalized. Recent evidence from mitochondrial protein import studies and other chaperone systems underscores the critical role of dynamics in balancing sufficiently tight binding, promiscuity, specificity, and release. Dynamic binding of client precursor proteins to import machinery components arises naturally from the avidity of their interactions. Conformational entropy enhances their stability, while the multivalent nature of these interactions ensures that client transfer to downstream insertases occurs without a substantial energy barrier. Here, we discuss this emerging paradigm of dynamic protein handling, using examples where dynamic structures have been resolved and highlight outstanding questions.","lang":"eng"}],"file_date_updated":"2026-06-02T07:23:12Z","volume":35,"external_id":{"pmid":["42159315"]},"scopus_import":"1","language":[{"iso":"eng"}],"quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","issue":"6","publication_status":"published","publication":"Protein Science","project":[{"name":"Structure and mechanism of the mitochondrial MIM insertase","_id":"bdb9578d-d553-11ed-ba76-ed5d39fce6f0","grant_number":"I06223"}],"OA_place":"publisher","_id":"21929","publisher":"Wiley","oa":1,"doi":"10.1002/pro.70630","title":"Dynamic disorder is crucial for mitochondrial protein import","PlanS_conform":"1","author":[{"full_name":"Schneider, Jakob","first_name":"Jakob","id":"64368429-eb97-11eb-a6c2-c980b1f44415","last_name":"Schneider"},{"last_name":"Guillerm","id":"bb74f472-ae54-11eb-9835-bc9c22fb1183","first_name":"Undina","full_name":"Guillerm, Undina"},{"last_name":"Simoes Pereira","id":"87266c4a-96d2-11ef-be2c-fe5633233ec3","first_name":"Caroline","full_name":"Simoes Pereira, Caroline"},{"last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606","first_name":"Paul","full_name":"Schanda, Paul"}],"oa_version":"Published Version","date_created":"2026-05-31T22:02:12Z","OA_type":"hybrid","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-06-02T07:26:34Z","corr_author":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"06","article_type":"original","has_accepted_license":"1","publication_identifier":{"eissn":["1469-896X"],"issn":["0961-8368"]},"file":[{"file_name":"2026_ProteinScience_Schneider.pdf","checksum":"e0163459a7238fdcc3fc5e17bedcce9a","date_created":"2026-06-02T07:23:12Z","date_updated":"2026-06-02T07:23:12Z","file_id":"21937","relation":"main_file","file_size":3897305,"content_type":"application/pdf","access_level":"open_access","success":1,"creator":"dernst"}],"year":"2026"}]