---
res:
  bibo_abstract:
  - "Selection against deleterious mutations, called purifying selection, plays a
    central role in evolution and acts in all populations. It is known that the genetic
    patterns observed in genomic regions undergoing purifying selection differ from
    those resulting from neutral evolution. However, a comprehensive understanding
    of the underlying mechanisms shaping those patterns is still lacking.\r\n\r\nIn
    the present work, we use simulations combined with a genealogical approach to
    identify the effect of purifying selection on the ancestry and thus on the genetic
    diversity. Our analysis relies on the postulate that the genealogy belongs to
    the universality class of Beta-coalescents. Under this assumption, we derive statistics
    measuring the distortion of the genealogy. This approach allows us to consider
    a wide range of regimes (i.e. arbitrary selection and mutation strengths) and
    uncover a rich phase diagram. We find that, for strong selection, the limiting
    genealogy is given by Kingman’s coalescent on a polynomial timescale. As selection
    gets weaker, Muller’s ratchet starts operating, setting off the emergence of multiple
    mergers in the genealogical structures. Our results show that while multiple-merger
    coalescents are often interpreted as the signature of selective sweeps in rapidly
    adapting populations, these structures can also appear in the context of Muller’s
    ratchet.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Kseniia
      foaf_name: Khudiakova, Kseniia
      foaf_surname: Khudiakova
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E6DC800-AE37-11E9-AC72-31CAE5697425
    orcid: 0000-0002-6246-1465
  - foaf_Person:
      foaf_givenName: Florin
      foaf_name: Boenkost, Florin
      foaf_surname: Boenkost
  - foaf_Person:
      foaf_givenName: Julie N
      foaf_name: Tourniaire, Julie N
      foaf_surname: Tourniaire
      foaf_workInfoHomepage: http://www.librecat.org/personId=5dc06dd8-8e51-11ec-9170-8d9c450cc216
  bibo_doi: 10.1101/2024.10.15.618444
  dct_date: 2024^xs_gYear
  dct_language: eng
  dct_title: Genealogies under purifying selection@
...