---
res:
  bibo_abstract:
  - 'We introduce JODIE, a genetic joint modeling approach that estimates how DNA
    loci influence human traits by partitioning genetic effects into four components:
    direct effects (from a child’s alleles), indirect maternal and paternal effects
    (from parents’ alleles), and parent-of-origin (PofO) effects (dependent on parental
    transmission of alleles), while uniquely accounting for assortative mating. We
    analyze 30,000 child-mother-father trios from the Estonian Biobank and the Norwegian
    Mother, Father, and Child Cohort, focusing on height, body mass index, and childhood
    educational test scores. We find direct effects to be the largest contributor
    to trait variation, but combined, indirect parental and PofO effects are similarly
    substantial. We support our results by within-family genome-wide association testing
    and identify 276 independently associated DNA regions with a complex interplay
    between direct, indirect, and PofO effects. By joint modeling, we show that direct,
    indirect, and PofO effects collectively shape human phenotypic variation across
    loci genome-wide.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Ilse
      foaf_name: Krätschmer, Ilse
      foaf_surname: Krätschmer
      foaf_workInfoHomepage: http://www.librecat.org/personId=30d4014e-7753-11eb-b44b-db6d61112e73
    orcid: 0000-0002-5636-9259
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Hegemann, Laura
      foaf_surname: Hegemann
  - foaf_Person:
      foaf_givenName: Robin J.
      foaf_name: Hofmeister, Robin J.
      foaf_surname: Hofmeister
  - foaf_Person:
      foaf_givenName: Elizabeth C.
      foaf_name: Corfield, Elizabeth C.
      foaf_surname: Corfield
  - foaf_Person:
      foaf_givenName: Mahdi
      foaf_name: Mahmoudi, Mahdi
      foaf_surname: Mahmoudi
  - foaf_Person:
      foaf_givenName: Olivier
      foaf_name: Delaneau, Olivier
      foaf_surname: Delaneau
  - foaf_Person:
      foaf_givenName: Ole A.
      foaf_name: Andreassen, Ole A.
      foaf_surname: Andreassen
  - foaf_Person:
      foaf_givenName: Archie
      foaf_name: Campbell, Archie
      foaf_surname: Campbell
  - foaf_Person:
      foaf_givenName: Caroline
      foaf_name: Hayward, Caroline
      foaf_surname: Hayward
  - foaf_Person:
      foaf_givenName: Riccardo E.
      foaf_name: Marioni, Riccardo E.
      foaf_surname: Marioni
  - foaf_Person:
      foaf_givenName: Eivind
      foaf_name: Ystrom, Eivind
      foaf_surname: Ystrom
  - foaf_Person:
      foaf_givenName: Alexandra
      foaf_name: Havdahl, Alexandra
      foaf_surname: Havdahl
  - foaf_Person:
      foaf_givenName: Matthew Richard
      foaf_name: Robinson, Matthew Richard
      foaf_surname: Robinson
      foaf_workInfoHomepage: http://www.librecat.org/personId=E5D42276-F5DA-11E9-8E24-6303E6697425
    orcid: 0000-0001-8982-8813
  bibo_doi: 10.1016/j.xgen.2026.101277
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2666-979X
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Separating direct, indirect, and parent-of-origin genetic effects in
    the human population@
  fabio_hasPubmedId: '40909755'
...