---
OA_type: closed access
_id: '21996'
abstract:
- lang: eng
  text: In this issue of Cell Host & Microbe, Osterman et al. discover aRES,1 a new
    family of bacterial immune proteins that deplete cellular NAD+, generating cleavage
    products that cannot be utilized by canonical phage NAD+ regeneration pathways.
    They identify the invader-specific trigger for aRES and characterize two distinct
    evolutionary countermeasures employed by phages to resist aRES.
acknowledgement: This work was supported by the Austrian Science Fund (FWF) (10.55776/PAT1617625).
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
  full_name: Williams-Jones, Daniel
  id: 128eaab9-b327-11f0-bdbe-e02d5abac73b
  last_name: Williams-Jones
- first_name: Jack Peter Kelly
  full_name: Bravo, Jack Peter Kelly
  id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
  last_name: Bravo
  orcid: 0000-0003-0456-0753
citation:
  ama: 'Williams-Jones D, Bravo JPK. NAD to the bone: How bacteria put phages under
    aRES-t … and how phages fight back. <i>Cell Host &#38; Microbe</i>. 2026;34(6):978-980.
    doi:<a href="https://doi.org/10.1016/j.chom.2026.05.013">10.1016/j.chom.2026.05.013</a>'
  apa: 'Williams-Jones, D., &#38; Bravo, J. P. K. (2026). NAD to the bone: How bacteria
    put phages under aRES-t … and how phages fight back. <i>Cell Host &#38; Microbe</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.chom.2026.05.013">https://doi.org/10.1016/j.chom.2026.05.013</a>'
  chicago: 'Williams-Jones, Daniel, and Jack Peter Kelly Bravo. “NAD to the Bone:
    How Bacteria Put Phages under ARES-t … and How Phages Fight Back.” <i>Cell Host
    &#38; Microbe</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.chom.2026.05.013">https://doi.org/10.1016/j.chom.2026.05.013</a>.'
  ieee: 'D. Williams-Jones and J. P. K. Bravo, “NAD to the bone: How bacteria put
    phages under aRES-t … and how phages fight back,” <i>Cell Host &#38; Microbe</i>,
    vol. 34, no. 6. Elsevier, pp. 978–980, 2026.'
  ista: 'Williams-Jones D, Bravo JPK. 2026. NAD to the bone: How bacteria put phages
    under aRES-t … and how phages fight back. Cell Host &#38; Microbe. 34(6), 978–980.'
  mla: 'Williams-Jones, Daniel, and Jack Peter Kelly Bravo. “NAD to the Bone: How
    Bacteria Put Phages under ARES-t … and How Phages Fight Back.” <i>Cell Host &#38;
    Microbe</i>, vol. 34, no. 6, Elsevier, 2026, pp. 978–80, doi:<a href="https://doi.org/10.1016/j.chom.2026.05.013">10.1016/j.chom.2026.05.013</a>.'
  short: D. Williams-Jones, J.P.K. Bravo, Cell Host &#38; Microbe 34 (2026) 978–980.
corr_author: '1'
das_tickbox: '1'
date_created: 2026-06-14T22:01:42Z
date_published: 2026-06-10T00:00:00Z
date_updated: 2026-06-22T07:11:28Z
day: '10'
department:
- _id: JaBr
doi: 10.1016/j.chom.2026.05.013
external_id:
  pmid:
  - '42269584'
intvolume: '        34'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 978-980
pmid: 1
publication: Cell Host & Microbe
publication_identifier:
  eissn:
  - 1934-6069
  issn:
  - 1931-3128
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'NAD to the bone: How bacteria put phages under aRES-t … and how phages fight
  back'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2026'
...