---
res:
  bibo_abstract:
  - Single stranded helically folded aromatic oligoamides bearing anionic phosphonate
    side chains have been shown to bind to some DNA-binding proteins better than DNA
    itself. However, these DNA mimic foldamers have until now mainly consisted of
    a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence
    information. Here, we introduce new monomers designed to display different chemical
    functionalities in the major groove of the DNA mimics. Four new Fmoc-protected
    amino acid monomers have been synthesized and incorporated into oligomers. Sixteen
    foldamer sequences were prepared on solid phase. Their conformation in solution
    and in the solid state and their conformational dynamics were investigated using
    NMR, circular dichroism, molecular modeling, and X-ray crystallography. The results
    show that three of four new monomers behaved as designed, and that their introduction
    enhances the conformational dynamics of the DNA mimic foldamers. In a fourth case,
    conformational behavior proved to be more complex than expected. The modified
    sequences retained an ability to bind to bacterial histone-like protein HU. These
    results showcase design strategies to manipulate large molecular biomimetics where
    not only side chains but also main chain components are varied. The new monomers
    pave the way to complex DNA mimic foldamer sequences targeting proteins that recognize
    sequence-selective DNA-binding proteins such as transcription factors or restriction
    enzymes.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jiaojiao
      foaf_name: Wu, Jiaojiao
      foaf_surname: Wu
  - foaf_Person:
      foaf_givenName: Valentina
      foaf_name: Corvaglia, Valentina
      foaf_surname: Corvaglia
  - foaf_Person:
      foaf_givenName: Tulika
      foaf_name: Chakrabortty, Tulika
      foaf_surname: Chakrabortty
  - foaf_Person:
      foaf_givenName: Pradeep K
      foaf_name: Mandal, Pradeep K
      foaf_surname: Mandal
      foaf_workInfoHomepage: http://www.librecat.org/personId=6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
    orcid: 0000-0001-5996-956X
  - foaf_Person:
      foaf_givenName: Ivan
      foaf_name: Huc, Ivan
      foaf_surname: Huc
  bibo_doi: 10.1039/d6sc00798h
  bibo_issue: '32'
  bibo_volume: 17
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-6520
  - http://id.crossref.org/issn/2041-6539
  dct_language: eng
  dct_publisher: Royal Society of Chemistry@
  dct_title: Tailoring the major groove of DNA mimic foldamers@
  fabio_hasPubmedId: '42388815'
...