---
res:
  bibo_abstract:
  - Hippocampal CA3 pyramidal neurons (PNs) form the largest autoassociative network
    in the mammalian brain. Whether CA3–CA3 recurrent connectivity is genetically
    preconfigured or environmentally shaped during ongoing memory storage is currently
    unknown. To address this question, we performed multicellular patch-clamp-based
    circuit mapping of up to eight CA3 PNs in the mouse hippocampus at multiple postnatal
    time points (P7–8, P18–25, and P45–50). Here, we show that the hippocampal CA3
    network undergoes a developmental transformation from local, dense, and random
    connectivity to a distributed, sparse, and structured configuration. Thus, sparse
    and structured connectivity may emerge via experience-dependent mechanisms. In
    parallel, the strength of single synapses is downregulated; single synaptic events
    are sufficient to trigger postsynaptic spiking early in development, whereas spatial
    summation of several inputs is required at later time points. Biologically inspired
    models of memory storage by Hebbian synaptic plasticity and retrieval via pattern
    completion suggest that developmental changes improve specific aspects of memory
    storage and retrieval. Our results imply a developmental transformation of the
    neuronal code and the memory functions in the hippocampal CA3 network.</jats:p>@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Victor M
      foaf_name: Vargas Barroso, Victor M
      foaf_surname: Vargas Barroso
      foaf_workInfoHomepage: http://www.librecat.org/personId=2F55A9DE-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Jake
      foaf_name: Watson, Jake
      foaf_surname: Watson
      foaf_workInfoHomepage: http://www.librecat.org/personId=63836096-4690-11EA-BD4E-32803DDC885E
    orcid: 0000-0002-8698-3823
  - foaf_Person:
      foaf_givenName: Andrea C
      foaf_name: Navas Olivé, Andrea C
      foaf_surname: Navas Olivé
      foaf_workInfoHomepage: http://www.librecat.org/personId=739d26c9-52e8-11ee-8d72-f14d3893b4ce
    orcid: 0000-0002-9280-8597
  - foaf_Person:
      foaf_givenName: Alois
      foaf_name: Schlögl, Alois
      foaf_surname: Schlögl
      foaf_workInfoHomepage: http://www.librecat.org/personId=45BF87EE-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-5621-8100
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1038/s41467-026-71914-x
  bibo_volume: 17
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Developmental emergence of sparse and structured synaptic connectivity
    in the hippocampal CA3 memory circuit@
  fabio_hasPubmedId: '42014695'
...