---
res:
  bibo_abstract:
  - The global rise of antimicrobial resistance has intensified the search for new
    microbial metabolites from underexplored environments and taxonomic groups. Extreme
    and geographically isolated habitats such as Antarctic terrestrial ecosystems
    represent promising reservoirs of biosynthetic diversity, particularly among rare
    and difficult-to-cultivate actinomycetes that may produce chemically diverse metabolites
    with potential biotechnological applications. Here, we report the characterization
    of kineochelins, a previously undescribed group of siderophores produced by the
    Antarctic isolate Actinokineospora sp. UV203, representing a difficult-to-cultivate
    actinomycete lineage. Structural elucidation revealed a set of closely related
    congeners with a mixed-ligand architecture consistent with metal-chelating activity.
    Genome mining combined with transcriptomic analysis identified a dedicated nonribosomal
    peptide synthetase-encoding biosynthetic gene cluster responsible for kineochelin
    production. Comparative genomic analyses indicated that, although kineochelin
    biosynthetic genes share limited similarity with known mixed-ligand siderophores,
    their gene content and organization differ substantially, suggesting a distinct
    biosynthetic lineage. Functional characterization of the culture supernatant and
    an enriched pre-purified kineochelin fraction demonstrated strong and selective
    iron chelation, with high affinity for ferric and ferrous iron. Crude culture
    extracts inhibited the growth of bacterial strains isolated from the same Antarctic
    environment, indicating that kineochelins may contribute to iron-mediated microbial
    competition. In addition, kineochelin-enriched pre-purified fractions showed moderate
    selective inhibitory activity against the opportunistic yeast pathogen Nakaseomyces
    glabratus and a clinical isolate of Saccharomyces cerevisiae associated with invasive
    infection. These findings expand the chemical and biosynthetic diversity known
    within the genus Actinokineospora and demonstrate that Antarctic rare actinomycetes
    represent valuable sources of previously unexplored natural products. The discovery
    of kineochelins highlights the potential of genome-guided exploration of polar
    microorganisms for identifying bioactive metabolites with relevance for antimicrobial
    discovery and biotechnology.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Stanislava
      foaf_name: Kralova, Stanislava
      foaf_surname: Kralova
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Spacek, Peter
      foaf_surname: Spacek
  - foaf_Person:
      foaf_givenName: Johannes
      foaf_name: Gafriller, Johannes
      foaf_surname: Gafriller
  - foaf_Person:
      foaf_givenName: Matej
      foaf_name: Bezdicek, Matej
      foaf_surname: Bezdicek
  - foaf_Person:
      foaf_givenName: Viktoria
      foaf_name: Medvedcova, Viktoria
      foaf_surname: Medvedcova
  - foaf_Person:
      foaf_givenName: Joana
      foaf_name: Séneca, Joana
      foaf_surname: Séneca
  - foaf_Person:
      foaf_givenName: Jay
      foaf_name: Osvatic, Jay
      foaf_surname: Osvatic
  - foaf_Person:
      foaf_givenName: Ulrike
      foaf_name: Grienke, Ulrike
      foaf_surname: Grienke
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Rattei, Thomas
      foaf_surname: Rattei
  - foaf_Person:
      foaf_givenName: Olga N.
      foaf_name: Sekurova, Olga N.
      foaf_surname: Sekurova
  - foaf_Person:
      foaf_givenName: Sergey B.
      foaf_name: Zotchev, Sergey B.
      foaf_surname: Zotchev
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Zehl, Martin
      foaf_surname: Zehl
      foaf_workInfoHomepage: http://www.librecat.org/personId=8e016d5b-5d77-11f0-86d2-96cdb3922a55
    orcid: 0000-0001-9685-0373
  - foaf_Person:
      foaf_givenName: Alexander
      foaf_name: Loy, Alexander
      foaf_surname: Loy
  bibo_doi: 10.1111/1751-7915.70386
  bibo_issue: '6'
  bibo_volume: 19
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1751-7915
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - Actinokineospora
  - Antarctica
  - antimicrobial discovery
  - biosynthetic gene cluster
  - genome mining
  - microbial competition
  - nonribosomalpeptide synthetase
  - siderophores
  dct_title: Kineochelins - A new group of siderophores from an antarctic bacterium@
  fabio_hasPubmedId: '42210522'
...