---
res:
  bibo_abstract:
  - The divisome apparatus synthesizes septal peptidoglycan (PG) during bacterial
    division. In Escherichia coli, the class A penicillin-binding protein (aPBP) called
    PBP1b has been implicated in division, but its role in the process has remained
    unclear. Here we show using in situ cryo-electron tomography, genetics and other
    imaging methods that PBP1b is required to produce a wedge-like density of PG at
    the division site and that loss of this structure weakens the division site, making
    it hypersusceptible to osmotic lysis. Surprisingly, the activator LpoB needed
    for general PBP1b function was not required for its role in division. Of the two
    PBP1b isoforms produced in cells, we show that the one with an extended cytoplasmic
    N terminus localizes to and functions at the division site, probably via recruitment
    by the FtsA component of the divisome. The conservation of aPBPs with extended
    cytoplasmic N termini suggests that other Gram-negative bacteria may use similar
    mechanisms for division site reinforcement.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Paula P.
      foaf_name: Navarro, Paula P.
      foaf_surname: Navarro
  - foaf_Person:
      foaf_givenName: Andrea
      foaf_name: Vettiger, Andrea
      foaf_surname: Vettiger
  - foaf_Person:
      foaf_givenName: Roman
      foaf_name: Hajdu, Roman
      foaf_surname: Hajdu
      foaf_workInfoHomepage: http://www.librecat.org/personId=ffab949d-133f-11ed-8f02-94de21ace503
  - foaf_Person:
      foaf_givenName: Virly Y.
      foaf_name: Ananda, Virly Y.
      foaf_surname: Ananda
  - foaf_Person:
      foaf_givenName: Alejandro
      foaf_name: López-Tavares, Alejandro
      foaf_surname: López-Tavares
  - foaf_Person:
      foaf_givenName: Ernst W.
      foaf_name: Schmid, Ernst W.
      foaf_surname: Schmid
  - foaf_Person:
      foaf_givenName: Johannes C.
      foaf_name: Walter, Johannes C.
      foaf_surname: Walter
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Loose, Martin
      foaf_surname: Loose
      foaf_workInfoHomepage: http://www.librecat.org/personId=462D4284-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7309-9724
  - foaf_Person:
      foaf_givenName: Luke H.
      foaf_name: Chao, Luke H.
      foaf_surname: Chao
  - foaf_Person:
      foaf_givenName: Thomas G.
      foaf_name: Bernhardt, Thomas G.
      foaf_surname: Bernhardt
  bibo_doi: 10.1038/s41564-026-02403-6
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2058-5276
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: The penicillin-binding protein PBP1b fortifies the Escherichia coli division
    site against osmotic rupture@
  fabio_hasPubmedId: '42399561'
...