---
res:
  bibo_abstract:
  - Tissue tension is a key determinant of tissue shape, and its regulation is essential
    for both morphogenesis and the maintenance of tissue integrity. During zebrafish
    embryogenesis, the enveloping layer (EVL) – an epithelial monolayer covering the
    blastoderm – undergoes extensive spreading that is driven by pulling forces exerted
    at its margin and more than doubles its surface area. Yet whether and how the
    EVL actively regulates its tissue tension during this process remains unclear.
    Here, we show that the EVL maintains constant tissue tension while spreading,
    and that it achieves this by reducing apical cell contractility in response to
    the same pulling forces that drive its spreading. We identify a mechanosensitive
    pathway underlying this response, mediated by the scaffold/adaptor protein Kibra
    regulating the activity of atypical protein kinase C (aPKC) at the apical domain
    of EVL cells. Under low mechanical stretch, Kibra forms condensates at the base
    of actin-based apical projections, where it activates Myosin II to increase apical
    contractility through aPKC downregulation. As mechanical stretch increases, apical
    projections disassemble, Kibra condensates dissolve, and aPKC activity rises.
    Elevated aPKC activity in turn reduces apical contractility by reducing Myosin
    II activity, thereby maintaining constant tissue tension despite increased mechanical
    stretch. Together, these findings reveal a mechanosensitive mechanism that enables
    robust adaptation of tissue tension to changing mechanical stretch, ensuring efficient
    tissue spreading and morphogenesis.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Naoya
      foaf_name: Hino, Naoya
      foaf_surname: Hino
      foaf_workInfoHomepage: http://www.librecat.org/personId=5299a9ce-7679-11eb-a7bc-d1e62b936307
  - foaf_Person:
      foaf_givenName: Tushna
      foaf_name: Kapoor, Tushna
      foaf_surname: Kapoor
      foaf_workInfoHomepage: http://www.librecat.org/personId=e3b3eda7-fd4d-11eb-8fd8-c40af7a478b1
  - foaf_Person:
      foaf_givenName: Uday R
      foaf_name: Gubbala, Uday R
      foaf_surname: Gubbala
      foaf_workInfoHomepage: http://www.librecat.org/personId=bb4a0dc4-32c9-11ee-b5ce-a97ceedd5924
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  dct_date: 2026^xs_gYear
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_subject:
  - Epithelial spreading
  - tissue tension
  - mechanosensation
  - aPKC
  - Kibra
  - zebrafish
  dct_title: Apical domain mechanosensation regulates tissue tension homeostasis@
...