---
res:
  bibo_abstract:
  - Single-stranded, helically folded aromatic oligoamides bearing anionic phosphonate
    side chains have been shown to bind to some DNA-binding proteins better than DNA
    itself. However, these DNA mimic foldamers have until now mainly consisted of
    a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence
    information. Here, we introduce new monomers designed to display different chemical
    functionalities in the major groove of the DNA mimics. Four new Fmoc-protected
    amino acid monomers have been synthesized and incorporated into oligomers. Sixteen
    foldamer sequences were prepared on solid phase. Their conformations in solution
    and in the solid state and their conformational dynamics were investigated using
    nuclear magnetic resonance, circular dichroism, molecular modeling, and X-ray
    crystallography. The results show that three of the four new monomers behaved
    as designed and that their introduction enhances the conformational dynamics of
    the DNA mimic foldamers. In a fourth case, conformational behavior proved to be
    more complex than expected. The modified sequences retained the ability to bind
    to the bacterial histone-like protein HU. These results showcase design strategies
    to manipulate large molecular biomimetics in which not only side chains but also
    main chain components are varied. The new monomers pave the way to complex DNA
    mimic foldamer sequences targeting proteins that recognize sequence-selective
    DNA-binding proteins such as transcription factors or restriction enzymes.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jiaojiao
      foaf_name: Wu, Jiaojiao
      foaf_surname: Wu
  - foaf_Person:
      foaf_givenName: Valentina
      foaf_name: Corvaglia, Valentina
      foaf_surname: Corvaglia
  - foaf_Person:
      foaf_givenName: Tulika
      foaf_name: Chakrabortty, Tulika
      foaf_surname: Chakrabortty
  - foaf_Person:
      foaf_givenName: Pradeep K
      foaf_name: Mandal, Pradeep K
      foaf_surname: Mandal
      foaf_workInfoHomepage: http://www.librecat.org/personId=6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
    orcid: 0000-0001-5996-956X
  - foaf_Person:
      foaf_givenName: Ivan
      foaf_name: Huc, Ivan
      foaf_surname: Huc
  bibo_doi: 10.1039/d6sc00798h
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-6520
  - http://id.crossref.org/issn/2041-6539
  dct_language: eng
  dct_publisher: Royal Society of Chemistry@
  dct_title: Tailoring the major groove of DNA mimic foldamers@
...