--- res: bibo_abstract: - 'Despite the functional diversity of over 100 causal genes1,2,3, phenotypic convergence across models may reveal common neurobiological processes in autism spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse models of ASD using single-nucleus multi-omic sequencing across three developmental stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked mutations converged on perturbations of the radial glial cell lineage. These alterations reflect a transient developmental delay rather than lasting lineage misspecification and resolve by postnatal stages. Molecularly, the largest transcriptional differences emerged in neurons at early postnatal stages. These changes included downregulation of synaptic and ion channel-related genes, consistent with homeostatic adaptation or delayed maturation. Network analysis showed molecular convergence across models within each developmental stage, suggesting that diverse mutations linked to ASD impinge on common, stage-specific processes. Convergence becomes less pronounced by postnatal day 14, highlighting the dynamic nature of ASD-associated changes. Cross-genotype heterogeneity is superimposed on stage-specific effects. Electrophysiology corroborated this pattern: mutants generally showed altered neuronal excitability and synaptic properties with model-specific nuances. Our study also highlighted sex-specific gene expression alterations, with female mice often displaying larger effect sizes than male mice. Together, our findings provide a comprehensive view of developmental cellular and molecular dynamics across models of ASD.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Lena A foaf_name: Schwarz, Lena A foaf_surname: Schwarz foaf_workInfoHomepage: http://www.librecat.org/personId=29A8453C-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Christoph foaf_name: Dotter, Christoph foaf_surname: Dotter foaf_workInfoHomepage: http://www.librecat.org/personId=4C66542E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-9033-9096 - foaf_Person: foaf_givenName: Sergey foaf_name: Isaev, Sergey foaf_surname: Isaev - foaf_Person: foaf_givenName: Michela foaf_name: Lisi, Michela foaf_surname: Lisi foaf_workInfoHomepage: http://www.librecat.org/personId=39383c1b-d3eb-11ef-8d6c-c8cdf4e10c8c - foaf_Person: foaf_givenName: Daniel foaf_name: Malzl, Daniel foaf_surname: Malzl - foaf_Person: foaf_givenName: Christoph foaf_name: Büschl, Christoph foaf_surname: Büschl foaf_workInfoHomepage: http://www.librecat.org/personId=2a8c054c-0913-11ee-9159-f8ef515809ed - foaf_Person: foaf_givenName: Sabrina foaf_name: Ladstätter, Sabrina foaf_surname: Ladstätter - foaf_Person: foaf_givenName: Bárbara foaf_name: Oliveira, Bárbara foaf_surname: Oliveira foaf_workInfoHomepage: http://www.librecat.org/personId=3B03AA1A-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Matteo foaf_name: Barel, Matteo foaf_surname: Barel foaf_workInfoHomepage: http://www.librecat.org/personId=8959927b-2236-11ed-bd6e-ea83d94ade0e - foaf_Person: foaf_givenName: Bernadette foaf_name: Basilico, Bernadette foaf_surname: Basilico foaf_workInfoHomepage: http://www.librecat.org/personId=36035796-5ACA-11E9-A75E-7AF2E5697425 orcid: 0000-0003-1843-3173 - foaf_Person: foaf_givenName: Chaitanya foaf_name: Chintaluri, Chaitanya foaf_surname: Chintaluri foaf_workInfoHomepage: http://www.librecat.org/personId=BA06AFEE-A4BA-11EA-AE5C-14673DDC885E orcid: 0000-0003-4252-1608 - foaf_Person: foaf_givenName: Sarah foaf_name: Gorkiewicz, Sarah foaf_surname: Gorkiewicz foaf_workInfoHomepage: http://www.librecat.org/personId=f141a35d-15a9-11ec-9fb2-fef6becc7b6f - foaf_Person: foaf_givenName: Mohammad foaf_name: Goudarzi, Mohammad foaf_surname: Goudarzi foaf_workInfoHomepage: http://www.librecat.org/personId=3384113A-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Tereza foaf_name: Belinova, Tereza foaf_surname: Belinova foaf_workInfoHomepage: http://www.librecat.org/personId=0bf89b6a-d28b-11eb-8bd6-f43768e4d368 - foaf_Person: foaf_givenName: Stephan foaf_name: Reichl, Stephan foaf_surname: Reichl - foaf_Person: foaf_givenName: Gintarė foaf_name: Sendžikaitė, Gintarė foaf_surname: Sendžikaitė foaf_workInfoHomepage: http://www.librecat.org/personId=dd6d52f2-c50d-11eb-9548-bcf0ff82b344 - foaf_Person: foaf_givenName: Satish foaf_name: Arcot Jayaram, Satish foaf_surname: Arcot Jayaram foaf_workInfoHomepage: http://www.librecat.org/personId=b0bbee33-09f7-11eb-909c-8b358058d28a orcid: 0000-0002-2479-2669 - foaf_Person: foaf_givenName: Peter foaf_name: Koppensteiner, Peter foaf_surname: Koppensteiner foaf_workInfoHomepage: http://www.librecat.org/personId=3B8B25A8-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-3509-1948 - foaf_Person: foaf_givenName: Christoph M foaf_name: Sommer, Christoph M foaf_surname: Sommer foaf_workInfoHomepage: http://www.librecat.org/personId=4DF26D8C-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-1216-9105 - foaf_Person: foaf_givenName: Tim P foaf_name: Vogels, Tim P foaf_surname: Vogels foaf_workInfoHomepage: http://www.librecat.org/personId=CB6FF8D2-008F-11EA-8E08-2637E6697425 orcid: 0000-0003-3295-6181 - foaf_Person: foaf_givenName: Jörg foaf_name: Menche, Jörg foaf_surname: Menche - foaf_Person: foaf_givenName: Igor foaf_name: Adameyko, Igor foaf_surname: Adameyko - foaf_Person: foaf_givenName: Peter Vasili foaf_name: Kharchenko, Peter Vasili foaf_surname: Kharchenko foaf_workInfoHomepage: http://www.librecat.org/personId=0095641e-7eb7-11f1-8665-aec51a2ab5e0 - foaf_Person: foaf_givenName: Christoph foaf_name: Bock, Christoph foaf_surname: Bock - foaf_Person: foaf_givenName: Gaia foaf_name: Novarino, Gaia foaf_surname: Novarino foaf_workInfoHomepage: http://www.librecat.org/personId=3E57A680-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-7673-7178 bibo_doi: 10.1038/s41586-026-10679-1 dct_date: 2026^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0028-0836 - http://id.crossref.org/issn/1476-4687 dct_language: eng dct_publisher: Springer Nature@ dct_title: Cortical development dynamics across autism spectrum disorder mouse models@ fabio_hasPubmedId: '42310454' ...