---
res:
  bibo_abstract:
  - Gravitropism is a fundamental adaptive response in plants that enables directional
    growth to optimize resource acquisition. In this study, we employed forward genetic
    screening to identify Arabidopsis mutants with defective hypocotyl gravitropism
    and isolated the short and agravitropic hypocotyl in dark1 (sad1) mutant, which
    carries a point mutation (G110E) in the SAC1 gene encoding a phosphoinositide
    phosphatase. Deficiency of SAC1 disrupted gravity-induced polar localization of
    PIN3 in endodermal cells, impairing auxin redistribution and leading to hypocotyl
    gravitropism defects. Subcellular localization analysis revealed that SAC1 is
    partially localized to the PVC/tonoplast and participates in late endosomal trafficking.
    The sac1 mutation leads to abnormal vacuolar morphology, which is associated with
    defects in amyloplast sedimentation during the gravitropic response in Arabidopsis
    shoots. We further revealed that SAC1 interacts with GRV2, a key regulator of
    the late endocytic pathway, and that both proteins cooperatively regulate shoot
    gravitropism. In summary, this study identified SAC1 as a regulator of shoot gravitropism,
    revealing its important role in modulating vacuolar homeostasis, amyloplast sedimentation,
    PIN3 trafficking, and auxin distribution. These findings provide insights into
    the molecular mechanisms linking membrane transport to environmental adaptation
    in plants.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Lianghanxiao
      foaf_name: Sun, Lianghanxiao
      foaf_surname: Sun
  - foaf_Person:
      foaf_givenName: Wenxin
      foaf_name: Jia, Wenxin
      foaf_surname: Jia
  - foaf_Person:
      foaf_givenName: Yanbo
      foaf_name: Mao, Yanbo
      foaf_surname: Mao
  - foaf_Person:
      foaf_givenName: Xin
      foaf_name: Li, Xin
      foaf_surname: Li
  - foaf_Person:
      foaf_givenName: Mengjuan
      foaf_name: Kong, Mengjuan
      foaf_surname: Kong
  - foaf_Person:
      foaf_givenName: Ji
      foaf_name: She, Ji
      foaf_surname: She
  - foaf_Person:
      foaf_givenName: Jiří
      foaf_name: Friml, Jiří
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  - foaf_Person:
      foaf_givenName: Shutang
      foaf_name: Tan, Shutang
      foaf_surname: Tan
      foaf_workInfoHomepage: http://www.librecat.org/personId=2DE75584-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0471-8285
  bibo_doi: 10.1111/tpj.71042
  bibo_issue: '1'
  bibo_volume: 127
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0960-7412
  - http://id.crossref.org/issn/1365-313X
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - auxin
  - SAC1
  - GRV2
  - PIN3
  - vacuole
  - gravitropism
  - Arabidopsis
  dct_title: Regulation of shoot gravitropism and branching angle by the GRV2-SAC1
    axis in Arabidopsis@
  fabio_hasPubmedId: '42438075'
...