---
res:
  bibo_abstract:
  - We report a unified method for the synthesis of α-polyhalomethyl amines from alkenes
    and alkynes, enabled by readily available hemiaminal reagents. This operationally
    simple transformation allows for the introduction of not only well-established
    CF3 and CF2H groups, but also the synthetically (and medicinally) underexplored
    CF2Cl and CFClH motifs—thereby broadening access to previously inaccessible chemical
    space of halogenated amine scaffolds. The method displays broad substrate scope
    and functional-group tolerance while operating under mild conditions. Late-stage
    functionalization of drug-like derivatives of Oxaprozin, Erlotinib, and Ibuprofen
    (among others) is reported.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Angela K.
      foaf_name: Hofmeister, Angela K.
      foaf_surname: Hofmeister
  - foaf_Person:
      foaf_givenName: Giulia
      foaf_name: Iannelli, Giulia
      foaf_surname: Iannelli
  - foaf_Person:
      foaf_givenName: Péter
      foaf_name: Angyal, Péter
      foaf_surname: Angyal
  - foaf_Person:
      foaf_givenName: Augustin
      foaf_name: Malandain, Augustin
      foaf_surname: Malandain
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Kaiser, Daniel
      foaf_surname: Kaiser
  - foaf_Person:
      foaf_givenName: Boris
      foaf_name: Maryasin, Boris
      foaf_surname: Maryasin
  - foaf_Person:
      foaf_givenName: Hanspeter
      foaf_name: Kählig, Hanspeter
      foaf_surname: Kählig
  - foaf_Person:
      foaf_givenName: Matteo
      foaf_name: Barel, Matteo
      foaf_surname: Barel
      foaf_workInfoHomepage: http://www.librecat.org/personId=8959927b-2236-11ed-bd6e-ea83d94ade0e
  - foaf_Person:
      foaf_givenName: Gaia
      foaf_name: Novarino, Gaia
      foaf_surname: Novarino
      foaf_workInfoHomepage: http://www.librecat.org/personId=3E57A680-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7673-7178
  - foaf_Person:
      foaf_givenName: Nuno
      foaf_name: Maulide, Nuno
      foaf_surname: Maulide
  bibo_doi: 10.1002/anie.1233707
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1433-7851
  - http://id.crossref.org/issn/1521-3773
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: Unified synthesis of unconventional α-polyhalogenated amines through
    hydroaminoalkylation@
  fabio_hasPubmedId: '42429166'
...