Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation Hofmeister, Angela K. Iannelli, Giulia Angyal, Péter Malandain, Augustin Kaiser, Daniel Maryasin, Boris Kählig, Hanspeter Barel, Matteo Novarino, Gaia ; https://orcid.org/0000-0002-7673-7178 Maulide, Nuno ddc:570 ddc:540 We report a unified method for the synthesis of α-polyhalomethyl amines from alkenes and alkynes, enabled by readily available hemiaminal reagents. This operationally simple transformation allows for the introduction of not only well-established CF3 and CF2H groups, but also the synthetically (and medicinally) underexplored CF2Cl and CFClH motifs—thereby broadening access to previously inaccessible chemical space of halogenated amine scaffolds. The method displays broad substrate scope and functional-group tolerance while operating under mild conditions. Late-stage functionalization of drug-like derivatives of Oxaprozin, Erlotinib, and Ibuprofen (among others) is reported. Wiley 2026 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/22370 Hofmeister AK, Iannelli G, Angyal P, et al. Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation. <i>Angewandte Chemie International Edition</i>. 2026. doi:<a href="https://doi.org/10.1002/anie.1233707">10.1002/anie.1233707</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1002/anie.1233707 info:eu-repo/semantics/altIdentifier/issn/1433-7851 info:eu-repo/semantics/altIdentifier/e-issn/1521-3773 info:eu-repo/semantics/altIdentifier/pmid/42429166 info:eu-repo/semantics/closedAccess