article epub_ahead yes Angela K. Hofmeister author Giulia Iannelli author Péter Angyal author Augustin Malandain author Daniel Kaiser author Boris Maryasin author Hanspeter Kählig author Matteo Barel author 8959927b-2236-11ed-bd6e-ea83d94ade0e Gaia Novarino author 3E57A680-F248-11E8-B48F-1D18A9856A870000-0002-7673-7178 Nuno Maulide author GaNo department GradSch department We report a unified method for the synthesis of α-polyhalomethyl amines from alkenes and alkynes, enabled by readily available hemiaminal reagents. This operationally simple transformation allows for the introduction of not only well-established CF3 and CF2H groups, but also the synthetically (and medicinally) underexplored CF2Cl and CFClH motifs—thereby broadening access to previously inaccessible chemical space of halogenated amine scaffolds. The method displays broad substrate scope and functional-group tolerance while operating under mild conditions. Late-stage functionalization of drug-like derivatives of Oxaprozin, Erlotinib, and Ibuprofen (among others) is reported. Wiley2026 eng 1433-7851 1521-3773 4242916610.1002/anie.1233707 A. K. Hofmeister <i>et al.</i>, “Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation,” <i>Angewandte Chemie International Edition</i>. Wiley, 2026. Hofmeister, Angela K., Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, and Nuno Maulide. “Unified Synthesis of Unconventional α-Polyhalogenated Amines through Hydroaminoalkylation.” <i>Angewandte Chemie International Edition</i>. Wiley, 2026. <a href="https://doi.org/10.1002/anie.1233707">https://doi.org/10.1002/anie.1233707</a>. A.K. Hofmeister, G. Iannelli, P. Angyal, A. Malandain, D. Kaiser, B. Maryasin, H. Kählig, M. Barel, G. Novarino, N. Maulide, Angewandte Chemie International Edition (2026). Hofmeister, A. K., Iannelli, G., Angyal, P., Malandain, A., Kaiser, D., Maryasin, B., … Maulide, N. (2026). Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation. <i>Angewandte Chemie International Edition</i>. Wiley. <a href="https://doi.org/10.1002/anie.1233707">https://doi.org/10.1002/anie.1233707</a> Hofmeister AK, Iannelli G, Angyal P, Malandain A, Kaiser D, Maryasin B, Kählig H, Barel M, Novarino G, Maulide N. 2026. Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation. Angewandte Chemie International Edition., e1233707. Hofmeister AK, Iannelli G, Angyal P, et al. Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation. <i>Angewandte Chemie International Edition</i>. 2026. doi:<a href="https://doi.org/10.1002/anie.1233707">10.1002/anie.1233707</a> Hofmeister, Angela K., et al. “Unified Synthesis of Unconventional α-Polyhalogenated Amines through Hydroaminoalkylation.” <i>Angewandte Chemie International Edition</i>, e1233707, Wiley, 2026, doi:<a href="https://doi.org/10.1002/anie.1233707">10.1002/anie.1233707</a>. 223702026-07-19T22:01:48Z2026-07-21T07:19:26Z