---
res:
  bibo_abstract:
  - Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization
    of organelles within cells, including endo-lysosomes, is a prerequisite of migration.
    However, how ultrastructural polarization is linked to the signaling requirements
    governing T cell migration remains unknown. Here we show that signaling molecules
    generated by endo-lysosome-localized kinases regulate velocity of amoeboid migration.
    Specifically, imaging of T cells identifies accumulation of endo-lysosomes decorated
    with the lipid kinases VPS34–PIKfyve at the uropod of polarized cells. Activity
    of VPS34 and PIKfyve regulates speed, but not directedness, of migrating T cells.
    Mechanistically, PI(3,5)P2 generated by the sequential action of VPS34 and PIKfyve,
    mediates Ca2+ efflux from lysosomes via the mucolipin TRP cation channel 1 (TRPML1),
    thus controlling activity of myosin IIA and hence the generation of propulsive
    force through retrograde actin flow. The VPS34–PIKfyve kinases also regulate velocity
    of myeloid cells, as well as of the amoeba Dictyostelium discoideum – establishing
    the axis as an evolutionarily conserved speed control system of amoeboid cell
    migration.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Philippe G
      foaf_name: Dehio, Philippe G
      foaf_surname: Dehio
      foaf_workInfoHomepage: http://www.librecat.org/personId=b769738e-a003-11ee-b1b8-9030316e0d59
  - foaf_Person:
      foaf_givenName: Céline
      foaf_name: Michard, Céline
      foaf_surname: Michard
  - foaf_Person:
      foaf_givenName: Juan Carlos
      foaf_name: Yam-Puc, Juan Carlos
      foaf_surname: Yam-Puc
  - foaf_Person:
      foaf_givenName: Adrià Arnau
      foaf_name: Martí I Líndez, Adrià Arnau
      foaf_surname: Martí I Líndez
  - foaf_Person:
      foaf_givenName: Anett
      foaf_name: Jandke, Anett
      foaf_surname: Jandke
  - foaf_Person:
      foaf_givenName: Gunhild
      foaf_name: Unterstab, Gunhild
      foaf_surname: Unterstab
  - foaf_Person:
      foaf_givenName: Lucien
      foaf_name: Fabre, Lucien
      foaf_surname: Fabre
  - foaf_Person:
      foaf_givenName: Loïc
      foaf_name: Sauteur, Loïc
      foaf_surname: Sauteur
  - foaf_Person:
      foaf_givenName: Marc
      foaf_name: Artinger, Marc
      foaf_surname: Artinger
  - foaf_Person:
      foaf_givenName: Daniel F.
      foaf_name: Legler, Daniel F.
      foaf_surname: Legler
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  - foaf_Person:
      foaf_givenName: Thorsten
      foaf_name: Schaefer, Thorsten
      foaf_surname: Schaefer
  - foaf_Person:
      foaf_givenName: Matthias P.
      foaf_name: Wymann, Matthias P.
      foaf_surname: Wymann
  - foaf_Person:
      foaf_givenName: Klaus
      foaf_name: Okkenhaug, Klaus
      foaf_surname: Okkenhaug
  - foaf_Person:
      foaf_givenName: Thierry
      foaf_name: Soldati, Thierry
      foaf_surname: Soldati
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Mehling, Matthias
      foaf_surname: Mehling
      foaf_workInfoHomepage: http://www.librecat.org/personId=3C23B994-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8599-1226
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Hess, Christoph
      foaf_surname: Hess
  bibo_doi: 10.1038/s44319-026-00861-x
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1469-3178
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of
    amoeboid cell migration@
  fabio_hasPubmedId: '42414599'
...