---
res:
  bibo_abstract:
  - Neurons acquire polarity by specifying one neurite as the axon, whereas the others
    become dendrites. But how this fundamental asymmetry is established remains unclear1.
    Neuronal polarization has been thought to rely primarily on growth cones that
    sense external cues2. Here we show that growth cones alone do not direct this
    process and that the soma acts as a central organizer of neuronal polarization.
    Using live imaging and genetic loss-of-function approaches in vivo, combined with
    optogenetic control and local cytoskeletal perturbations in cultured neurons,
    we uncover a soma-initiated oscillatory program that primes axon selection. Periodic
    actin branching that depends on the actin-related protein 2/3 (ARP2/3) complex
    at the soma remodels a global actomyosin network, thereby generating an actin
    wave that retracts neurites before propagating into a single neurite tip. Exposure
    to this wave relaxes local actomyosin contractility, which drives a transient
    microtubule-based protrusion and biases this neurite towards axon fate. As the
    cell exits this oscillatory stage, this neurite can overcome global inhibition
    and extend independently of ARP2/3, whereas actomyosin activity suppresses axon
    formation in the remaining neurites so that they subsequently become dendrites.
    This soma-driven mechanism ensures the emergence of a single axon independent
    of environmental cues and underpins the unidirectional information flow in neuronal
    circuits.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Tien Chen
      foaf_name: Lin, Tien Chen
      foaf_surname: Lin
  - foaf_Person:
      foaf_givenName: Charlotte H.
      foaf_name: Coles, Charlotte H.
      foaf_surname: Coles
  - foaf_Person:
      foaf_givenName: Eissa
      foaf_name: Alfadil, Eissa
      foaf_surname: Alfadil
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Fäßler, Florian
      foaf_surname: Fäßler
      foaf_workInfoHomepage: http://www.librecat.org/personId=404F5528-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7149-769X
  - foaf_Person:
      foaf_givenName: Andreas
      foaf_name: Husch, Andreas
      foaf_surname: Husch
  - foaf_Person:
      foaf_givenName: Sebastian
      foaf_name: Dupraz, Sebastian
      foaf_surname: Dupraz
  - foaf_Person:
      foaf_givenName: Thorben
      foaf_name: Pietralla, Thorben
      foaf_surname: Pietralla
  - foaf_Person:
      foaf_givenName: Akihiro
      foaf_name: Narita, Akihiro
      foaf_surname: Narita
  - foaf_Person:
      foaf_givenName: Max
      foaf_name: Schelski, Max
      foaf_surname: Schelski
  - foaf_Person:
      foaf_givenName: Kevin C.
      foaf_name: Flynn, Kevin C.
      foaf_surname: Flynn
  - foaf_Person:
      foaf_givenName: Sina
      foaf_name: Stern, Sina
      foaf_surname: Stern
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Möhl, Christoph
      foaf_surname: Möhl
  - foaf_Person:
      foaf_givenName: Brett J.
      foaf_name: Hilton, Brett J.
      foaf_surname: Hilton
  - foaf_Person:
      foaf_givenName: Franz
      foaf_name: Vauti, Franz
      foaf_surname: Vauti
  - foaf_Person:
      foaf_givenName: Hans Henning
      foaf_name: Arnold, Hans Henning
      foaf_surname: Arnold
  - foaf_Person:
      foaf_givenName: Florian Km
      foaf_name: Schur, Florian Km
      foaf_surname: Schur
      foaf_workInfoHomepage: http://www.librecat.org/personId=48AD8942-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4790-8078
  - foaf_Person:
      foaf_givenName: Frank
      foaf_name: Bradke, Frank
      foaf_surname: Bradke
  bibo_doi: 10.1038/s41586-026-10755-6
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0028-0836
  - http://id.crossref.org/issn/1476-4687
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: An intrinsic cytoskeletal oscillator establishes neuronal polarity@
  fabio_hasPubmedId: '42420447'
...