---
res:
  bibo_abstract:
  - "Gaining an understanding of how biological regulation evolves is a fundamental
    research \r\nquestion in both evolutionary biology and molecular genetics. In
    order to gain more insight \r\ninto this topic, we focus on studying the simple
    gene regulatory system of the lac operon in \r\nE. coli. We show that simple population
    genetic models can shed light on evolution \r\nexperiments and that this combined
    approach of modelling the experimental system gives \r\ninsight to better understand
    the causes of evolutionary change in the experiment. We also \r\nstudy the natural
    diversity in the lac operon from 308 publicly available E. coli genomes that \r\ncome
    from various host species and different regions of the world. Evidence that selection
    is \r\ngenerally maintaining the function of the lac operon across the sample
    regardless of host \r\nspecies is provided and we show that different protein
    coding genes in the operon are under \r\ndifferent selective constraints on protein
    sequence preservation. A similar frameshift \r\nmutation found in experimental
    evolution studies is shown to be present in the sample we \r\nanalyzed, indicating
    that selectively relevant variants in evolution experiments are also \r\npresent
    in natural populations. We show that there is no simple phylogenetic relationship
    \r\nbetween host species, geographical location and the lac operon sequence. Finally,
    we argue \r\nthat a combined approach of comparative genomics, experimental evolution
    and theoretical \r\nmodelling contributes to a more complete understanding of
    molecular evolution. @eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Aleksa
      foaf_name: Spasić, Aleksa
      foaf_surname: Spasić
      foaf_workInfoHomepage: http://www.librecat.org/personId=ecee9d38-4040-11ef-8843-b941efb445d6
  bibo_doi: 10.15479/AT-ISTA-22399
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2791-4585
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_title: Studying the evolutionary systems biology of the lac operon@
...