---
_id: '2242'
abstract:
- lang: eng
  text: MicroRNAs (miRNAs) are small RNAs that play important regulatory roles in
    many cellular pathways. MiRNAs associate with members of the Argonaute protein
    family and bind to partially complementary sequences on mRNAs and induce translational
    repression or mRNA decay. Using deep sequencing and Northern blotting, we characterized
    miRNA expression in wild type and miR-155-deficient dendritic cells (DCs) and
    macrophages. Analysis of different stimuli (LPS, LDL, eLDL, oxLDL) reveals a direct
    influence of miR-155 on the expression levels of other miRNAs. For example, miR-455
    is negatively regulated in miR-155-deficient cells possibly due to inhibition
    of the transcription factor C/EBPbeta by miR-155. Based on our comprehensive data
    sets, we propose a model of hierarchical miRNA expression dominated by miR-155
    in DCs and macrophages.
article_processing_charge: No
author:
- first_name: Anne
  full_name: Dueck, Anne
  last_name: Dueck
- first_name: Alexander
  full_name: Eichner, Alexander
  id: 4DFA52AE-F248-11E8-B48F-1D18A9856A87
  last_name: Eichner
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Gunter
  full_name: Meister, Gunter
  last_name: Meister
citation:
  ama: Dueck A, Eichner A, Sixt MK, Meister G. A miR-155-dependent microRNA hierarchy
    in dendritic cell maturation and macrophage activation. <i>FEBS Letters</i>. 2014;588(4):632-640.
    doi:<a href="https://doi.org/10.1016/j.febslet.2014.01.009">10.1016/j.febslet.2014.01.009</a>
  apa: Dueck, A., Eichner, A., Sixt, M. K., &#38; Meister, G. (2014). A miR-155-dependent
    microRNA hierarchy in dendritic cell maturation and macrophage activation. <i>FEBS
    Letters</i>. Elsevier. <a href="https://doi.org/10.1016/j.febslet.2014.01.009">https://doi.org/10.1016/j.febslet.2014.01.009</a>
  chicago: Dueck, Anne, Alexander Eichner, Michael K Sixt, and Gunter Meister. “A
    MiR-155-Dependent MicroRNA Hierarchy in Dendritic Cell Maturation and Macrophage
    Activation.” <i>FEBS Letters</i>. Elsevier, 2014. <a href="https://doi.org/10.1016/j.febslet.2014.01.009">https://doi.org/10.1016/j.febslet.2014.01.009</a>.
  ieee: A. Dueck, A. Eichner, M. K. Sixt, and G. Meister, “A miR-155-dependent microRNA
    hierarchy in dendritic cell maturation and macrophage activation,” <i>FEBS Letters</i>,
    vol. 588, no. 4. Elsevier, pp. 632–640, 2014.
  ista: Dueck A, Eichner A, Sixt MK, Meister G. 2014. A miR-155-dependent microRNA
    hierarchy in dendritic cell maturation and macrophage activation. FEBS Letters.
    588(4), 632–640.
  mla: Dueck, Anne, et al. “A MiR-155-Dependent MicroRNA Hierarchy in Dendritic Cell
    Maturation and Macrophage Activation.” <i>FEBS Letters</i>, vol. 588, no. 4, Elsevier,
    2014, pp. 632–40, doi:<a href="https://doi.org/10.1016/j.febslet.2014.01.009">10.1016/j.febslet.2014.01.009</a>.
  short: A. Dueck, A. Eichner, M.K. Sixt, G. Meister, FEBS Letters 588 (2014) 632–640.
date_created: 2018-12-11T11:56:31Z
date_published: 2014-02-14T00:00:00Z
date_updated: 2025-09-29T11:19:23Z
day: '14'
department:
- _id: MiSi
doi: 10.1016/j.febslet.2014.01.009
external_id:
  isi:
  - '000331115700016'
intvolume: '       588'
isi: 1
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 632 - 640
publication: FEBS Letters
publication_identifier:
  issn:
  - 0014-5793
publication_status: published
publisher: Elsevier
publist_id: '4714'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage
  activation
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 588
year: '2014'
...