---
_id: '2254'
abstract:
- lang: eng
  text: Theta-gamma network oscillations are thought to represent key reference signals
    for information processing in neuronal ensembles, but the underlying synaptic
    mechanisms remain unclear. To address this question, we performed whole-cell (WC)
    patch-clamp recordings from mature hippocampal granule cells (GCs) in vivo in
    the dentate gyrus of anesthetized and awake rats. GCs in vivo fired action potentials
    at low frequency, consistent with sparse coding in the dentate gyrus. GCs were
    exposed to barrages of fast AMPAR-mediated excitatory postsynaptic currents (EPSCs),
    primarily relayed from the entorhinal cortex, and inhibitory postsynaptic currents
    (IPSCs), presumably generated by local interneurons. EPSCs exhibited coherence
    with the field potential predominantly in the theta frequency band, whereas IPSCs
    showed coherence primarily in the gamma range. Action potentials in GCs were phase
    locked to network oscillations. Thus, theta-gamma-modulated synaptic currents
    may provide a framework for sparse temporal coding of information in the dentate
    gyrus.
article_processing_charge: No
author:
- first_name: Alejandro
  full_name: Pernia-Andrade, Alejandro
  id: 36963E98-F248-11E8-B48F-1D18A9856A87
  last_name: Pernia-Andrade
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Pernia-Andrade A, Jonas PM. Theta-gamma-modulated synaptic currents in hippocampal
    granule cells in vivo define a mechanism for network oscillations. <i>Neuron</i>.
    2014;81(1):140-152. doi:<a href="https://doi.org/10.1016/j.neuron.2013.09.046">10.1016/j.neuron.2013.09.046</a>
  apa: Pernia-Andrade, A., &#38; Jonas, P. M. (2014). Theta-gamma-modulated synaptic
    currents in hippocampal granule cells in vivo define a mechanism for network oscillations.
    <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2013.09.046">https://doi.org/10.1016/j.neuron.2013.09.046</a>
  chicago: Pernia-Andrade, Alejandro, and Peter M Jonas. “Theta-Gamma-Modulated Synaptic
    Currents in Hippocampal Granule Cells in Vivo Define a Mechanism for Network Oscillations.”
    <i>Neuron</i>. Elsevier, 2014. <a href="https://doi.org/10.1016/j.neuron.2013.09.046">https://doi.org/10.1016/j.neuron.2013.09.046</a>.
  ieee: A. Pernia-Andrade and P. M. Jonas, “Theta-gamma-modulated synaptic currents
    in hippocampal granule cells in vivo define a mechanism for network oscillations,”
    <i>Neuron</i>, vol. 81, no. 1. Elsevier, pp. 140–152, 2014.
  ista: Pernia-Andrade A, Jonas PM. 2014. Theta-gamma-modulated synaptic currents
    in hippocampal granule cells in vivo define a mechanism for network oscillations.
    Neuron. 81(1), 140–152.
  mla: Pernia-Andrade, Alejandro, and Peter M. Jonas. “Theta-Gamma-Modulated Synaptic
    Currents in Hippocampal Granule Cells in Vivo Define a Mechanism for Network Oscillations.”
    <i>Neuron</i>, vol. 81, no. 1, Elsevier, 2014, pp. 140–52, doi:<a href="https://doi.org/10.1016/j.neuron.2013.09.046">10.1016/j.neuron.2013.09.046</a>.
  short: A. Pernia-Andrade, P.M. Jonas, Neuron 81 (2014) 140–152.
corr_author: '1'
date_created: 2018-12-11T11:56:35Z
date_published: 2014-01-08T00:00:00Z
date_updated: 2026-04-16T10:08:53Z
day: '08'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2013.09.046
ec_funded: 1
external_id:
  isi:
  - '000329559000015'
file:
- access_level: open_access
  checksum: 438547cfcd9045a22f065f2019f07849
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:48Z
  date_updated: 2020-07-14T12:45:35Z
  file_id: '4773'
  file_name: IST-2016-422-v1+1_1-s2.0-S0896627313009227-main.pdf
  file_size: 4373072
  relation: main_file
file_date_updated: 2020-07-14T12:45:35Z
has_accepted_license: '1'
intvolume: '        81'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 140 - 152
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
publication: Neuron
publication_identifier:
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4692'
pubrep_id: '422'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Theta-gamma-modulated synaptic currents in hippocampal granule cells in vivo
  define a mechanism for network oscillations
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 81
year: '2014'
...