---
res:
  bibo_abstract:
  - For tissues to spread, they must deform while staying intact. How spreading tissues
    balance flexibility with integrity is not yet well understood. Here, we show that
    keratin intermediate filaments adapt tissue mechanical resilience to the stresses
    arising in epithelial tissues during spreading. By analyzing the expansion of
    the enveloping cell layer (EVL) over the yolk cell in zebrafish embryos in vivo,
    we find that keratin network maturation in EVL cells is promoted by stresses building
    up within the spreading tissue. Through genetic interference and tissue rheology
    experiments, complemented by a vertex model with mechanochemical feedback, we
    demonstrate that stress-induced keratin network maturation in the EVL increases
    tissue viscosity, to prevent tissue rupture. Further, keratins are required in
    the yolk cell for mechanosensitive actomyosin network contraction and flow, the
    forces pulling the EVL. These dual mechanosensitive functions of keratins enable
    a balance between pulling force production and EVL mechanical resilience, ensuring
    uniform and robust tissue spreading.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Suyash
      foaf_name: Naik, Suyash
      foaf_surname: Naik
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C0B105C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8421-5508
  - foaf_Person:
      foaf_givenName: Yann-Edwin
      foaf_name: Keta, Yann-Edwin
      foaf_surname: Keta
  - foaf_Person:
      foaf_givenName: Kornelija
      foaf_name: Pranjic-Ferscha, Kornelija
      foaf_surname: Pranjic-Ferscha
      foaf_workInfoHomepage: http://www.librecat.org/personId=4362B3C2-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Silke
      foaf_name: Henkes, Silke
      foaf_surname: Henkes
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  bibo_doi: 10.1038/s41467-026-72366-z
  bibo_volume: 17
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Keratins coordinate tissue spreading by balancing spreading forces with
    tissue material properties@
  fabio_hasPubmedId: '42143048'
...