[{"author":[{"first_name":"Desmond","last_name":"Bradley","full_name":"Bradley, Desmond"},{"first_name":"Louis","last_name":"Boell","full_name":"Boell, Louis"},{"first_name":"Daniel","full_name":"Richardson, Daniel","last_name":"Richardson"},{"last_name":"Copsey","full_name":"Copsey, Lucy","first_name":"Lucy"},{"first_name":"Annabel","last_name":"Whibley","full_name":"Whibley, Annabel"},{"first_name":"Ting","full_name":"Xu, Ting","last_name":"Xu"},{"full_name":"Zhang, Yu’E","last_name":"Zhang","first_name":"Yu’E"},{"last_name":"Xue","full_name":"Xue, Yongbiao","first_name":"Yongbiao"},{"id":"419049E2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4014-8478","first_name":"David","last_name":"Field","full_name":"Field, David"},{"first_name":"Enrico","full_name":"Coen, Enrico","last_name":"Coen"}],"department":[{"_id":"NiBa"}],"language":[{"iso":"eng"}],"_id":"22620","das_tickbox":"1","publisher":"AAAS","date_created":"2026-08-02T22:01:53Z","scopus_import":"1","article_processing_charge":"Yes","year":"2026","file_date_updated":"2026-08-03T09:44:40Z","volume":12,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","OA_type":"gold","oa":1,"PlanS_conform":"1","publication_status":"published","corr_author":"1","intvolume":"        12","supplementarymaterial":"yes","publication":"Science Advances","issue":"29","citation":{"chicago":"Bradley, Desmond, Louis Boell, Daniel Richardson, Lucy Copsey, Annabel Whibley, Ting Xu, Yu’E Zhang, Yongbiao Xue, David Field, and Enrico Coen. “Shaping of Developmental Gradients through Selection on Multiple Loci in Antirrhinum.” <i>Science Advances</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/sciadv.adx2011\">https://doi.org/10.1126/sciadv.adx2011</a>.","apa":"Bradley, D., Boell, L., Richardson, D., Copsey, L., Whibley, A., Xu, T., … Coen, E. (2026). Shaping of developmental gradients through selection on multiple loci in Antirrhinum. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.adx2011\">https://doi.org/10.1126/sciadv.adx2011</a>","short":"D. Bradley, L. Boell, D. Richardson, L. Copsey, A. Whibley, T. Xu, Y. Zhang, Y. Xue, D. Field, E. Coen, Science Advances 12 (2026) 1–11.","ama":"Bradley D, Boell L, Richardson D, et al. Shaping of developmental gradients through selection on multiple loci in Antirrhinum. <i>Science Advances</i>. 2026;12(29):1-11. doi:<a href=\"https://doi.org/10.1126/sciadv.adx2011\">10.1126/sciadv.adx2011</a>","ista":"Bradley D, Boell L, Richardson D, Copsey L, Whibley A, Xu T, Zhang Y, Xue Y, Field D, Coen E. 2026. Shaping of developmental gradients through selection on multiple loci in Antirrhinum. Science Advances. 12(29), 1–11.","mla":"Bradley, Desmond, et al. “Shaping of Developmental Gradients through Selection on Multiple Loci in Antirrhinum.” <i>Science Advances</i>, vol. 12, no. 29, AAAS, 2026, pp. 1–11, doi:<a href=\"https://doi.org/10.1126/sciadv.adx2011\">10.1126/sciadv.adx2011</a>.","ieee":"D. Bradley <i>et al.</i>, “Shaping of developmental gradients through selection on multiple loci in Antirrhinum,” <i>Science Advances</i>, vol. 12, no. 29. AAAS, pp. 1–11, 2026."},"publication_identifier":{"eissn":["2375-2548"]},"month":"07","doi":"10.1126/sciadv.adx2011","type":"journal_article","day":"17","DOAJ_listed":"1","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Development depends on precise shaping of molecular gradients, but how natural selection acts to establish precision is unknown. Here, we analyze genes that control differences in the gradient of yellow flower color between two varieties of snapdragon (Antirrhinum). We show that these differences depend, in part, on cis-regulatory variation in the pigment biosynthetic gene, FLAVIA (FLA). FLA interacts multiplicatively with three other loci, one of which is a trans-acting regulator of FLA, to further shape the yellow gradient. All the loci exhibit clines at a hybrid zone, with widths that correlate with phenotypic effect, showing how selection can hone gradient shape with remarkable precision by acting on cis and trans variation at multiple loci."}],"file":[{"file_id":"22635","content_type":"application/pdf","date_created":"2026-08-03T09:44:40Z","file_size":916329,"date_updated":"2026-08-03T09:44:40Z","file_name":"2026_ScienceAdv_Bradley.pdf","success":1,"checksum":"f9155dc2d9273e43c0caf78dffa96864","creator":"dernst","access_level":"open_access","relation":"main_file"}],"license":"https://creativecommons.org/licenses/by/4.0/","researchdata_availability":"no","date_published":"2026-07-17T00:00:00Z","pmid":1,"dataavailabilitystatement":"All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. All materials generated in this study are described in Materials and Methods and are available on request from E.C. (enrico.coen@jic.ac.uk).","date_updated":"2026-08-03T09:52:37Z","acknowledgement":"We thank C. Taylor for plant care, N. Barton for sharing SNP data and useful comments, H. Tavares for useful discussions and bioinformatics, M. Couchman for field and data archiving, T. Li for help with photography and phenotyping, J. Chan for help with ImageJ analyses, and X. Rebocho for organization of field experiments. This work was supported by Biotechnology and Biological Sciences Research Council grants BB/S009256/1 (to E.C.), BB/G009325/1 (to E.C.), BBS/E/JI/230002C (to E.C.), and BBS/E/J/000PR9773 (to E.C.); Biotechnology Biological Sciences Research Council Norwich Research Park Biosciences Doctoral Training Partnership grant BB/M011216/1 (to D.R.); and Natural Science Foundation of China grant 32030007 (to Y.X.)","article_type":"original","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"ddc":["570"],"title":"Shaping of developmental gradients through selection on multiple loci in Antirrhinum","external_id":{"pmid":["42467783"]},"page":"1-11","status":"public","quality_controlled":"1","OA_place":"publisher"}]