---
res:
  bibo_abstract:
  - Nestin-cre transgenic mice have been widely used to direct recombination to neural
    stem cells (NSCs) and intermediate neural progenitor cells (NPCs). Here we report
    that a readily utilized, and the only commercially available, Nestin-cre line
    is insufficient for directing recombination in early embryonic NSCs and NPCs.
    Analysis of recombination efficiency in multiple cre-dependent reporters and a
    genetic mosaic line revealed consistent temporal and spatial patterns of recombination
    in NSCs and NPCs. For comparison we utilized a knock-in Emx1cre line and found
    robust recombination in NSCs and NPCs in ventricular and subventricular zones
    of the cerebral cortices as early as embryonic day 12.5. In addition we found
    that the rate of Nestin-cre driven recombination only reaches sufficiently high
    levels in NSCs and NPCs during late embryonic and early postnatal periods. These
    findings are important when commercially available cre lines are considered for
    directing recombination to embryonic NSCs and NPCs.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Huixuan
      foaf_name: Liang, Huixuan
      foaf_surname: Liang
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  - foaf_Person:
      foaf_givenName: H.
      foaf_name: Ghashghaei, H.
      foaf_surname: Ghashghaei
  bibo_doi: 10.1242/bio.20122287
  bibo_issue: '12'
  bibo_volume: 1
  dct_date: 2012^xs_gYear
  dct_identifier:
  - UT:000209205700005
  dct_language: eng
  dct_publisher: The Company of Biologists@
  dct_title: A Nestin-cre transgenic mouse is insufficient for recombination in early
    embryonic neural progenitors@
...