--- res: bibo_abstract: - Faithful progression through the cell cycle is crucial to the maintenance and developmental potential of stem cells. Here, we demonstrate that neural stem cells (NSCs) and intermediate neural progenitor cells (NPCs) employ a zinc-finger transcription factor specificity protein 2 (Sp2) as a cell cycle regulator in two temporally and spatially distinct progenitor domains. Differential conditional deletion of Sp2 in early embryonic cerebral cortical progenitors, and perinatal olfactory bulb progenitors disrupted transitions through G1, G2 and M phases, whereas DNA synthesis appeared intact. Cell-autonomous function of Sp2 was identified by deletion of Sp2 using mosaic analysis with double markers, which clearly established that conditional Sp2-null NSCs and NPCs are M phase arrested in vivo. Importantly, conditional deletion of Sp2 led to a decline in the generation of NPCs and neurons in the developing and postnatal brains. Our findings implicate Sp2-dependent mechanisms as novel regulators of cell cycle progression, the absence of which disrupts neurogenesis in the embryonic and postnatal brain.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Huixuan foaf_name: Liang, Huixuan foaf_surname: Liang - foaf_Person: foaf_givenName: Guanxi foaf_name: Xiao, Guanxi foaf_surname: Xiao - foaf_Person: foaf_givenName: Haifeng foaf_name: Yin, Haifeng foaf_surname: Yin - foaf_Person: foaf_givenName: Simon foaf_name: Hippenmeyer, Simon foaf_surname: Hippenmeyer foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-2279-1061 - foaf_Person: foaf_givenName: Jonathan foaf_name: Horowitz, Jonathan foaf_surname: Horowitz - foaf_Person: foaf_givenName: Troy foaf_name: Ghashghaei, Troy foaf_surname: Ghashghaei bibo_doi: 10.1242/dev.085621 bibo_issue: '3' bibo_volume: 140 dct_date: 2013^xs_gYear dct_language: eng dct_publisher: Company of Biologists@ dct_title: Neural development is dependent on the function of specificity protein 2 in cell cycle progression@ fabio_hasPubmedId: '23293287' ...