---
OA_place: repository
_id: '22704'
abstract:
- lang: eng
  text: "The medial habenula (MHb) is implicated in regulating emotional responses
    to aversive events. Studies in zebrafish have identified a remarkable morphological
    left–right asymmetry in the dorsal habenula (zebrafish equivalent of mammalian
    MHb)-interpeduncular nucleus (IPN) pathway and its asymmetrical roles in behavior.
    However, there is little evidence for structural or functional lateralization
    in the mammalian MHb-IPN pathway. Here, we investigated the synaptic properties
    of left- and right-MHb afferents to the IPN and their roles in the expression
    of conditioned fear in mice. We found that each IPN neuron receives inputs from
    both left and right MHb, but the left MHb-originating synapses exhibit lower release
    probability and higher γ-aminobutyric acid type B receptor (GABABR)-mediated potentiation
    compared to the right MHb-originating synapses. Interestingly, these asymmetrical
    properties persist in the inversus visceral mutant mice with normal internal organ
    laterality (situs solitus), but nearly disappear in those with reversed internal
    organ laterality (situs inversus). Behaviorally, chemogenetic inhibition of cholinergic
    neurons and conditional deletion of GABABR in the left, but not the right, MHb
    significantly attenuated cue-dependent fear recall. Our results demonstrate functional
    asymmetry of the MHb under partial influence of the nodal flow in mice, revealing
    a predominant role of GABABR-mediated signaling in the left MHb-IPN pathway in
    modulating fear memories. These findings suggest that lateralized MHb pathways
    could represent a fundamental principle in the neural regulation of emotion across
    species but that they develop differently in zebrafish and mice.\r\n"
acknowledged_ssus:
- _id: M-Shop
- _id: PreCl
article_processing_charge: No
author:
- first_name: Elodie
  full_name: Le Monnier, Elodie
  id: 3B59276A-F248-11E8-B48F-1D18A9856A87
  last_name: Le Monnier
- first_name: Cihan
  full_name: Önal, Cihan
  last_name: Önal
citation:
  ama: Le Monnier E, Önal C. Asymmetrical modulation of fear expression via GABAB
    receptors in the mouse medial habenula. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22704">10.15479/AT-ISTA-22704</a>
  apa: Le Monnier, E., &#38; Önal, C. (2026). Asymmetrical modulation of fear expression
    via GABAB receptors in the mouse medial habenula. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/AT-ISTA-22704">https://doi.org/10.15479/AT-ISTA-22704</a>
  chicago: Le Monnier, Elodie, and Cihan Önal. “Asymmetrical Modulation of Fear Expression
    via GABAB Receptors in the Mouse Medial Habenula.” Institute of Science and Technology
    Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22704">https://doi.org/10.15479/AT-ISTA-22704</a>.
  ieee: E. Le Monnier and C. Önal, “Asymmetrical modulation of fear expression via
    GABAB receptors in the mouse medial habenula.” Institute of Science and Technology
    Austria, 2026.
  ista: Le Monnier E, Önal C. 2026. Asymmetrical modulation of fear expression via
    GABAB receptors in the mouse medial habenula, Institute of Science and Technology
    Austria, <a href="https://doi.org/10.15479/AT-ISTA-22704">10.15479/AT-ISTA-22704</a>.
  mla: Le Monnier, Elodie, and Cihan Önal. <i>Asymmetrical Modulation of Fear Expression
    via GABAB Receptors in the Mouse Medial Habenula</i>. Institute of Science and
    Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22704">10.15479/AT-ISTA-22704</a>.
  short: E. Le Monnier, C. Önal, (2026).
corr_author: '1'
date_created: 2026-08-13T12:20:08Z
date_published: 2026-08-13T00:00:00Z
date_updated: 2026-08-13T13:30:37Z
day: '13'
department:
- _id: RySh
doi: 10.15479/AT-ISTA-22704
doi_confirm: '1'
ec_funded: 1
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has_accepted_license: '1'
month: '08'
oa: 1
oa_version: None
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 92503f6e-16d5-11f0-9cad-8c571927f3b7
  grant_number: PAT 5720324
  name: New regime of presynaptic release regulation
publisher: Institute of Science and Technology Austria
status: public
title: Asymmetrical modulation of fear expression via GABAB receptors in the mouse
  medial habenula
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...