---
res:
  bibo_abstract:
  - Circadian clocks underlie daily rhythms in physiology by coordinating temporal
    patterns of gene expression and protein function throughout the body. At the core
    of this system in mammals is CLOCK/BMAL1, a ubiquitously expressed heterodimeric
    transcription factor complex that orchestrates tissue-specific circadian gene
    expression. The basis for this specificity remains unclear, but tissue-specific
    interactions at chromatin could provide one. Here we used chromatin immunoprecipitation
    coupled to mass spectrometry to map CLOCK/BMAL1-associated protein complexes on
    chromatin in mouse liver, kidney and lung. We detected 1,510 associated proteins,
    most of which were tissue-specific and not explained by protein abundance. Among
    these, we identified the homeodomain transcription factors PROX1, HNF1B and HOXA5
    as tissue-enriched interactors that bind BMAL1, co-occupy most BMAL1 genomic sites
    and establish organ-restricted circadian transcription. Our findings demonstrate
    that tissue-specific transcription factors confer cellular identity on the core
    clock, thereby contributing to organ-specific patterns of rhythmic gene expression.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Fatih
      foaf_name: Aygenli, Fatih
      foaf_surname: Aygenli
  - foaf_Person:
      foaf_givenName: Lukas A.
      foaf_name: Huschet, Lukas A.
      foaf_surname: Huschet
  - foaf_Person:
      foaf_givenName: Tanja
      foaf_name: Popp, Tanja
      foaf_surname: Popp
  - foaf_Person:
      foaf_givenName: Andrea
      foaf_name: Ribeiro, Andrea
      foaf_surname: Ribeiro
  - foaf_Person:
      foaf_givenName: Darina
      foaf_name: Barkhatova, Darina
      foaf_surname: Barkhatova
      foaf_workInfoHomepage: http://www.librecat.org/personId=db547c8c-329f-11ee-a353-cde802618f9e
    orcid: 0000-0002-0062-2817
  - foaf_Person:
      foaf_givenName: Céline
      foaf_name: Jouffe, Céline
      foaf_surname: Jouffe
  - foaf_Person:
      foaf_givenName: Ricardo
      foaf_name: Trozzo, Ricardo
      foaf_surname: Trozzo
  - foaf_Person:
      foaf_givenName: Jerome S.
      foaf_name: Menet, Jerome S.
      foaf_surname: Menet
  - foaf_Person:
      foaf_givenName: Roland
      foaf_name: Rad, Roland
      foaf_surname: Rad
  - foaf_Person:
      foaf_givenName: Kenneth A.
      foaf_name: Dyar, Kenneth A.
      foaf_surname: Dyar
  - foaf_Person:
      foaf_givenName: Maciej
      foaf_name: Lech, Maciej
      foaf_surname: Lech
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Straub, Tobias
      foaf_surname: Straub
  - foaf_Person:
      foaf_givenName: Alicia
      foaf_name: Michael, Alicia
      foaf_surname: Michael
      foaf_workInfoHomepage: http://www.librecat.org/personId=6437c950-2a03-11ee-914d-d6476dd7b75c
    orcid: 0000-0002-6080-839X
  - foaf_Person:
      foaf_givenName: Maria S.
      foaf_name: Robles, Maria S.
      foaf_surname: Robles
  bibo_doi: 10.1038/s41556-026-02041-4
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1465-7392
  - http://id.crossref.org/issn/1476-4679
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators@
  fabio_hasPubmedId: '42562924'
...