{"page":"182","oa_version":"Published Version","language":[{"iso":"eng"}],"month":"08","publication_status":"published","author":[{"last_name":"Michalik","full_name":"Michalik, David","id":"B9577E20-AA38-11E9-AC9A-0930E6697425","first_name":"David"}],"department":[{"_id":"CaBe"},{"_id":"GradSch"}],"acknowledgement":"This research was supported by the Scientific Service Units of Institute of Science and\r\nTechnology Austria through resources provided by the Lab Support Facility and Electron\r\nMicroscopy Facility at ISTA. Monoclonal Antibody Facility at Max Perutz laboratories are\r\nacknowledged for raising anti-pSer1022 MDA5 antibody. Proteomics core facility CEITEC MUNI\r\nBrno, namely David Pospíšil, are acknowledged for their help with measuring MS data as well\r\nas help with interpreting them and the introduction into MS data analysis. CIISB, Instruct-CZ\r\nCentre of Instruct-ERIC EU consortium, funded by MEYS CR infrastructure project LM2023042,\r\nis gratefully acknowledged for the financial support of the measurements at the CEITEC\r\nProteomics Core Facility. Computational resources were provided by the e-INFRA CZ project\r\n(ID:90254), supported by MEYS CR.\r\nThis work was supported by the Austrian Science Fund (FWF) grant F8003-B RNA-DECO:\r\nDecorating RNA for a purpose (10.55776/F80).","ddc":["572"],"corr_author":"1","citation":{"ista":"Michalik D. 2026. Mechanistic insights into MDA5 selectivity and regulation. Institute of Science and Technology Austria.","mla":"Michalik, David. <i>Mechanistic Insights into MDA5 Selectivity and Regulation</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22745\">10.15479/AT-ISTA-22745</a>.","chicago":"Michalik, David. “Mechanistic Insights into MDA5 Selectivity and Regulation.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22745\">https://doi.org/10.15479/AT-ISTA-22745</a>.","ieee":"D. Michalik, “Mechanistic insights into MDA5 selectivity and regulation,” Institute of Science and Technology Austria, 2026.","short":"D. Michalik, Mechanistic Insights into MDA5 Selectivity and Regulation, Institute of Science and Technology Austria, 2026.","apa":"Michalik, D. (2026). <i>Mechanistic insights into MDA5 selectivity and regulation</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22745\">https://doi.org/10.15479/AT-ISTA-22745</a>","ama":"Michalik D. Mechanistic insights into MDA5 selectivity and regulation. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22745\">10.15479/AT-ISTA-22745</a>"},"alternative_title":["ISTA Thesis"],"degree_awarded":"PhD","has_accepted_license":"1","OA_place":"publisher","supervisor":[{"first_name":"Carrie A","id":"2CB9DFE2-F248-11E8-B48F-1D18A9856A87","full_name":"Bernecky, Carrie A","last_name":"Bernecky","orcid":"0000-0003-0893-7036"}],"file_date_updated":"2026-08-26T08:46:35Z","year":"2026","doi_confirm":"1","date_published":"2026-08-21T00:00:00Z","_id":"22745","date_created":"2026-08-21T09:29:34Z","type":"dissertation","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","day":"21","publication_identifier":{"issn":["2663-337X"]},"file":[{"content_type":"application/pdf","file_id":"22763","checksum":"cd80d2076a5155ab6a12ec0b05adbee5","date_updated":"2026-08-26T08:46:02Z","embargo":"2027-08-26","file_name":"2026_Michalik_David_Thesis.pdf","relation":"main_file","date_created":"2026-08-26T08:46:02Z","embargo_to":"open_access","creator":"cchlebak","file_size":13624837,"access_level":"closed"},{"date_updated":"2026-08-26T08:46:35Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"22764","checksum":"16ae6cd206ba0eb04ce8a7198042f24f","date_created":"2026-08-26T08:46:35Z","relation":"source_file","file_size":20499216,"creator":"cchlebak","access_level":"closed","file_name":"2026_Michalik_David_Thesis.docx"}],"publisher":"Institute of Science and Technology Austria","title":"Mechanistic insights into MDA5 selectivity and regulation","tmp":{"image":"/images/cc_by_sa.png","short":"CC BY-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)"},"project":[{"name":"RNAdeco: decorating RNA for a purpose","grant_number":"F8003","_id":"059C9F64-7A3F-11EA-A408-12923DDC885E"}],"date_updated":"2026-08-28T08:34:46Z","doi":"10.15479/AT-ISTA-22745","status":"public"}