---
res:
  bibo_abstract:
  - Radial glial progenitors (RGPs) produce all excitatory neurons in the developing
    cerebral cortex. Mosaic analysis with double markers (MADM)-based lineage tracing
    in vivo has revealed a quantitative framework of RGP lineage progression1. Here
    we established MADM technology2,3 in mouse embryonic stem cells to probe RGP lineage
    progression in a self-organizing cortical organoid system. We found that RGPs
    exhibit a high level of plasticity in proliferative potential in organoids rather
    than strict temporally stereotyped lineage progression as observed in vivo. RGPs
    in organoids showed increased lineage restriction, diminishing cell-type diversity
    in clones of cortical projection neurons, despite uniform single-cell transcriptional
    signatures of RGPs and a unitary lineage trajectory. Thus, critical non-cell-autonomous
    cues that are absent in self-organizing systems and/or the genuine stem cell niche
    are essential for faithful temporal control of RGP lineage progression and the
    generation of clonal cortical cell-type diversity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Melissa A
      foaf_name: Stouffer, Melissa A
      foaf_surname: Stouffer
      foaf_workInfoHomepage: http://www.librecat.org/personId=4C9372C4-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Osvaldo
      foaf_name: Miranda, Osvaldo
      foaf_surname: Miranda
      foaf_workInfoHomepage: http://www.librecat.org/personId=862A3C56-A8BF-11E9-B4FA-D9E3E5697425
    orcid: 0000-0001-6618-6889
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Pauler, Florian
      foaf_surname: Pauler
      foaf_workInfoHomepage: http://www.librecat.org/personId=48EA0138-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7462-0048
  - foaf_Person:
      foaf_givenName: Fabrizia
      foaf_name: Pipicelli, Fabrizia
      foaf_surname: Pipicelli
      foaf_workInfoHomepage: http://www.librecat.org/personId=649134fd-d012-11ed-8f82-db1e5050f9ba
  - foaf_Person:
      foaf_givenName: Carmen
      foaf_name: Streicher, Carmen
      foaf_surname: Streicher
      foaf_workInfoHomepage: http://www.librecat.org/personId=36BCB99C-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Giselle T
      foaf_name: Cheung, Giselle T
      foaf_surname: Cheung
      foaf_workInfoHomepage: http://www.librecat.org/personId=471195F6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8457-2572
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  bibo_doi: 10.1038/s41586-026-10916-7
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0028-0836
  - http://id.crossref.org/issn/1476-4687
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Temporal uncoupling of radial glia lineage progression in cortical organoids@
  fabio_hasPubmedId: '42587153'
...