---
res:
  bibo_abstract:
  - 'Cleavage - the series of rapid cell divisions that follow fertilization - marks
    the onset of metazoan development and represents a deeply conserved evolutionary
    process. Across animals, two principal modes exist: complete (holoblastic) and
    incomplete (meroblastic) cleavage. While holoblastic cleavage resembles conventional
    cytokinesis both in vitro and in vivo, the mechanisms underlying meroblastic cleavage
    have remained poorly understood. Using zebrafish embryos as a model, we show that
    meroblastic cleavage proceeds through a distinct two-step mechanism. The process
    begins with the assembly and contraction of a large, arc-shaped actomyosin cable.
    However, this contractile event alone is insufficient to complete division. A
    second phase, driven by cadherin-mediated membrane adhesion, is required to invaginate
    the furrow ridge. Strikingly, this transition depends on mechanical uncoupling
    of the contractile cable from the surrounding cortex. We demonstrate that such
    uncoupling arises from an active nematic instability, which both enhances contractility
    along the cable and generates actin depletion zones that relieve lateral connections.
    Together, these findings reveal that meroblastic cleavage is governed not by a
    single actomyosin-based event but by a sequential interplay between cytoskeletal
    contraction and cadherin-dependent adhesion, highlighting a mechanism fundamentally
    distinct from canonical cytokinesis.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Xin
      foaf_name: Tong, Xin
      foaf_surname: Tong
      foaf_workInfoHomepage: http://www.librecat.org/personId=50F65CDC-AA30-11E9-A72B-8A12E6697425
  - foaf_Person:
      foaf_givenName: Yuting I
      foaf_name: Li, Yuting I
      foaf_surname: Li
      foaf_workInfoHomepage: http://www.librecat.org/personId=ee7a5ca8-8b71-11ed-b662-b3341c05b7eb
  - foaf_Person:
      foaf_givenName: Joséphine
      foaf_name: Schelle, Joséphine
      foaf_surname: Schelle
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  bibo_doi: 10.1101/2025.10.15.682552
  dct_date: 2025^xs_gYear
  dct_language: eng
  dct_title: Non-canonical cytokinesis driven by mechanical uncoupling via nematic
    flows and adhesion-based invagination@
...