---
OA_place: repository
OA_type: green
_id: '22870'
abstract:
- lang: eng
  text: 'Abstract: Chromosomal rearrangements can lead to the coupling of reproductive
    barriers, but whether and how they contribute to completion of speciation remains
    unclear. Marine snails of the genus Littorina repeatedly form hybrid zones between
    populations segregating for multiple inversion arrangements, providing opportunities
    to study their barrier effects. Here, we analysed two adjacent transects across
    hybrid zones between two ecotypes of Littorina fabalis (‘large’ and ‘dwarf’) adapted
    to different wave exposure conditions on a Swedish island. Applying whole-genome
    sequencing, we found 12 putative inversions on nine of 17 chromosomes. Nine of
    the putative inversions reached near differential fixation between the two ecotypes,
    and all were in strong linkage disequilibrium. These inversions cover 20% of the
    genome and carry 93% of divergent single nucleotide polymorphisms (SNPs). Bimodal
    hybrid zones in both transects indicated that the two ecotypes of Littorina fabalis
    maintain their genetic and phenotypic integrity following contact. The bimodality
    reflects the strong coupling between inversion clines and the extension of the
    barrier effect across the whole genome. Demographic inference suggests that coupling
    arose during a period of allopatry and has been maintained for >1000 generations
    after secondary contact. Overall, this study shows that the coupling of multiple
    chromosomal inversions contributes to strong reproductive isolation. Notably,
    two of the putative inversions overlap with inverted genomic regions associated
    with ecotype differences in a closely-related species (Littorina saxatilis), suggesting
    the same regions, with similar structural variants, repeatedly contribute to ecotype
    evolution in distinct species.'
article_processing_charge: No
author:
- first_name: Alan
  full_name: Le Moan, Alan
  last_name: Le Moan
citation:
  ama: Le Moan A. Coupling of twelve putative chromosomal inversions maintains a strong
    barrier to gene flow between snail ecotypes. 2024. doi:<a href="https://doi.org/10.5281/zenodo.10790257">10.5281/zenodo.10790257</a>
  apa: Le Moan, A. (2024). Coupling of twelve putative chromosomal inversions maintains
    a strong barrier to gene flow between snail ecotypes. Repository. <a href="https://doi.org/10.5281/zenodo.10790257">https://doi.org/10.5281/zenodo.10790257</a>
  chicago: Le Moan, Alan. “Coupling of Twelve Putative Chromosomal Inversions Maintains
    a Strong Barrier to Gene Flow between Snail Ecotypes.” Repository, 2024. <a href="https://doi.org/10.5281/zenodo.10790257">https://doi.org/10.5281/zenodo.10790257</a>.
  ieee: A. Le Moan, “Coupling of twelve putative chromosomal inversions maintains
    a strong barrier to gene flow between snail ecotypes.” Repository, 2024.
  ista: Le Moan A. 2024. Coupling of twelve putative chromosomal inversions maintains
    a strong barrier to gene flow between snail ecotypes, Repository, <a href="https://doi.org/10.5281/zenodo.10790257">10.5281/zenodo.10790257</a>.
  mla: Le Moan, Alan. <i>Coupling of Twelve Putative Chromosomal Inversions Maintains
    a Strong Barrier to Gene Flow between Snail Ecotypes</i>. Repository, 2024, doi:<a
    href="https://doi.org/10.5281/zenodo.10790257">10.5281/zenodo.10790257</a>.
  short: A. Le Moan, (2024).
contributor:
- contributor_type: contact_person
  first_name: Alan
  last_name: Le Moan
date_created: 2026-09-09T10:39:08Z
date_published: 2024-03-06T00:00:00Z
date_updated: 2026-09-09T10:39:13Z
day: '06'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5281/zenodo.10790257
fulldoi: https://doi.org/10.5281/zenodo.10790257
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5281/zenodo.10790257
month: '03'
oa: 1
oa_version: None
publisher: Repository
related_material:
  record:
  - id: '18908'
    relation: used_in_publication
    status: public
status: public
title: Coupling of twelve putative chromosomal inversions maintains a strong barrier
  to gene flow between snail ecotypes
type: research_data_reference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2024'
...