---
res:
  bibo_abstract:
  - Many biological machines function through controlled conformational transitions,
    yet designing synthetic nanostructures with prescribed dynamical behavior remains
    a major challenge. Here, we develop a modular inverse-design framework for bistable
    nanostructures whose function is controlled by an energy profile along a geometric
    reaction coordinate. Inspired by proteins with rigid domains connected by flexible
    hinges, we introduce a hinge-arm paradigm in which a small bistable hinge controls
    the energetics of a conformational transition, while rigid arms map this transition
    onto the separation between external binding sites. Specifically, we ask which
    features of a target energy profile can be programmed under different design constraints.
    We find that the energy barriers and the binding-site separations in the two metastable
    states can be readily designed, while controlling the location of the transition
    state or the full shape of the energy profile requires additional design freedom.
    Using a differentiable design framework, we find that some optimized solutions
    are numerically inexact but still display the functional behavior for which the
    target profile was selected, emphasizing the importance of function-based evaluation
    criteria. These results establish a practical hierarchy of designability for bistable
    nanostructures and provide a route toward synthetic nanomachines that couple conformational
    transitions to target behavior.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Andreas
      foaf_name: Ehrmann, Andreas
      foaf_surname: Ehrmann
      foaf_workInfoHomepage: http://www.librecat.org/personId=eaa689ed-f6e0-11ea-865d-bd98cbcf83c2
    orcid: 0000-0002-0997-5678
  - foaf_Person:
      foaf_givenName: Marija
      foaf_name: Krstić, Marija
      foaf_surname: Krstić
      foaf_workInfoHomepage: http://www.librecat.org/personId=a8f6d1c6-3200-11ee-973b-dab948eace26
  - foaf_Person:
      foaf_givenName: Sahar
      foaf_name: Samadzadeh, Sahar
      foaf_surname: Samadzadeh
      foaf_workInfoHomepage: http://www.librecat.org/personId=0099896b-5fb8-11ef-8420-b30b14627e93
  - foaf_Person:
      foaf_givenName: Carl Peter
      foaf_name: Goodrich, Carl Peter
      foaf_surname: Goodrich
      foaf_workInfoHomepage: http://www.librecat.org/personId=EB352CD2-F68A-11E9-89C5-A432E6697425
    orcid: 0000-0002-1307-5074
  bibo_doi: 10.48550/arXiv.2606.31620
  dct_date: 2026^xs_gYear
  dct_language: eng
  dct_title: Designing bistable nanostructures for target behavior@
...