---
res:
  bibo_abstract:
  - The shape of animal cells is controlled by their surface, which comprises the
    cell cortex, a peripheral actin network, tethered to the plasma membrane by membrane-to-cortex
    attachment proteins. Changes in cortical components have long been considered
    to dominate the regulation of forces and mechanical properties at the cell surface
    and drive morphogenesis. Here, we show that the coupling of the cortex to the
    membrane is also key for the regulation of its mechanical properties. By combining
    molecular engineering with biophysical approaches and in-cell cryo-electron tomography
    we describe the cell surface with nanometer-resolution and link its organization
    to cell-scale mechanics. We find that membrane-to-cortex attachment proteins can
    physically draw the cortex closer to the membrane, in a density and length-dependent
    manner. This reduction of the membrane-to-cortex distance controls the activity
    of the formin mDia1, leading to a reduction in cortical tension. Our study thus
    defines a novel mechanism whereby the membrane-to-cortex distance is a functional
    geometrical parameter that regulates cell surface properties.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Léanne
      foaf_name: Strauss, Léanne
      foaf_surname: Strauss
  - foaf_Person:
      foaf_givenName: Sergio
      foaf_name: Lembo, Sergio
      foaf_surname: Lembo
      foaf_workInfoHomepage: http://www.librecat.org/personId=d993a7b2-292f-11ed-aaac-fb045a912e31
    orcid: 0000-0002-2253-8771
  - foaf_Person:
      foaf_givenName: Samuel F.
      foaf_name: Gérard, Samuel F.
      foaf_surname: Gérard
  - foaf_Person:
      foaf_givenName: Marc
      foaf_name: Siggel, Marc
      foaf_surname: Siggel
  - foaf_Person:
      foaf_givenName: Dorothy
      foaf_name: Cheng, Dorothy
      foaf_surname: Cheng
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Bergert, Martin
      foaf_surname: Bergert
  - foaf_Person:
      foaf_givenName: Sarah K.
      foaf_name: Foster, Sarah K.
      foaf_surname: Foster
  - foaf_Person:
      foaf_givenName: Joseph
      foaf_name: Vermeil, Joseph
      foaf_surname: Vermeil
  - foaf_Person:
      foaf_givenName: Mauricio
      foaf_name: Toro-Nahuelpan, Mauricio
      foaf_surname: Toro-Nahuelpan
  - foaf_Person:
      foaf_givenName: Lena M.
      foaf_name: Fischer, Lena M.
      foaf_surname: Fischer
  - foaf_Person:
      foaf_givenName: Qin
      foaf_name: Yu, Qin
      foaf_surname: Yu
  - foaf_Person:
      foaf_givenName: Ewa
      foaf_name: Sitarska, Ewa
      foaf_surname: Sitarska
  - foaf_Person:
      foaf_givenName: Chii Jou
      foaf_name: Chan, Chii Jou
      foaf_surname: Chan
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Kosinski, Jan
      foaf_surname: Kosinski
  - foaf_Person:
      foaf_givenName: Matthieu
      foaf_name: Piel, Matthieu
      foaf_surname: Piel
  - foaf_Person:
      foaf_givenName: Olivia
      foaf_name: Du Roure, Olivia
      foaf_surname: Du Roure
  - foaf_Person:
      foaf_givenName: Julien
      foaf_name: Heuvingh, Julien
      foaf_surname: Heuvingh
  - foaf_Person:
      foaf_givenName: Julia
      foaf_name: Mahamid, Julia
      foaf_surname: Mahamid
  - foaf_Person:
      foaf_givenName: Alba
      foaf_name: Diz-Muñoz, Alba
      foaf_surname: Diz-Muñoz
  bibo_doi: 10.1038/s41467-026-72845-3
  bibo_volume: 17
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: The membrane-to-cortex distance regulates mDia1 activity to control cortical
    mechanics@
  fabio_hasPubmedId: '42697882'
...