---
res:
  bibo_abstract:
  - Argonaute proteins mediate RNA interference in eukaryotes and nucleic‐acid defence
    in prokaryotes. Although these systems operate in distinct biological contexts
    and produce diverse downstream outcomes, they share a conserved structural architecture
    and mechanism of guide‐dependent target recognition. Here, we argue that Argonautes
    function as programmable surveillance platforms that kinetically sample nucleic
    acids, engage targets through sequential pairing and conformational checkpoints,
    and couple recognition to functional outputs through regulated structural transitions.
    Rather than representing distinct recognition mechanisms, the diverse targeting
    behaviours observed across Argonaute families reflect different implementations
    of this shared framework, in which guide biogenesis, target accessibility, pairing
    requirements and effector coupling are weighted differently according to biological
    context. Viewing Argonautes through this common operational logic reconciles apparent
    differences in specificity, mismatch tolerance and target selection across systems,
    while providing a unified conceptual framework for understanding their evolution
    and guiding the engineering of programmable nucleic‐acid recognition technologies.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jack Peter Kelly
      foaf_name: Bravo, Jack Peter Kelly
      foaf_surname: Bravo
      foaf_workInfoHomepage: http://www.librecat.org/personId=96aecfa5-8931-11ee-af30-aa6a5d6eee0e
    orcid: 0000-0003-0456-0753
  bibo_doi: 10.1002/1873-3468.70450
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0014-5793
  - http://id.crossref.org/issn/1873-3468
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: ‘Guide and Prejudice’ -  How Argonautes recognize targets across domains
    of life@
  fabio_hasPubmedId: '42711859'
...