@article{22952,
  abstract     = {Mechanosensitive ion transport plays a central role in enabling living systems to perceive and adapt to their environment through the deformation of soft, embedded ion channels. In this work, we demonstrate that ion transport within a two-dimensional graphite nanoslit can be rationally engineered to achieve a bipolar, pressure-sensitive response without any structural deformation. The mechanosensitivity arises from the selective charging of one channel inlet, which acts as a reversible source of mobile charge carriers. These excess ions can then be advected in or out of the channel by the pressure-driven water flow, thereby modulating the ionic conductance. This mechanism is captured through a comprehensive electrohydrodynamic model that analytically accounts for coupled diffusion, convection, surface transport, diffusio-osmosis, and interfacial slippage, both inside and outside the nanoslit. The theoretical framework quantitatively reproduces the experimental data, showing that a simple surface charge pattern can give rise to complex, pressure-dependent conductance. These findings reveal how rich nonlinear couplings at the nanoscale can be harnessed to design adaptive, bioinspired nanofluidic systems, exemplified here by ionic pressure sensors.},
  author       = {Lizée, Mathieu and Zhang, Zhijia and Coquinot, Baptiste and Yang, Qian and Bocquet, Lydéric},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {31},
  publisher    = {AAAS},
  title        = {{Architecting mechanosensitive nanofluidic transport in graphite nanoslits}},
  doi          = {10.1126/sciadv.aed4451},
  volume       = {12},
  year         = {2026},
}