Architecting mechanosensitive nanofluidic transport in graphite nanoslits Lizée, Mathieu Zhang, Zhijia Coquinot, Baptiste ; https://orcid.org/0000-0001-5524-596X Yang, Qian Bocquet, Lydéric ddc:530 Mechanosensitive ion transport plays a central role in enabling living systems to perceive and adapt to their environment through the deformation of soft, embedded ion channels. In this work, we demonstrate that ion transport within a two-dimensional graphite nanoslit can be rationally engineered to achieve a bipolar, pressure-sensitive response without any structural deformation. The mechanosensitivity arises from the selective charging of one channel inlet, which acts as a reversible source of mobile charge carriers. These excess ions can then be advected in or out of the channel by the pressure-driven water flow, thereby modulating the ionic conductance. This mechanism is captured through a comprehensive electrohydrodynamic model that analytically accounts for coupled diffusion, convection, surface transport, diffusio-osmosis, and interfacial slippage, both inside and outside the nanoslit. The theoretical framework quantitatively reproduces the experimental data, showing that a simple surface charge pattern can give rise to complex, pressure-dependent conductance. These findings reveal how rich nonlinear couplings at the nanoscale can be harnessed to design adaptive, bioinspired nanofluidic systems, exemplified here by ionic pressure sensors. AAAS 2026 info:eu-repo/semantics/article doc-type:Article Article http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/22952 https://research-explorer.ista.ac.at/download/22952/22989 Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. Architecting mechanosensitive nanofluidic transport in graphite nanoslits. <i>Science Advances</i>. 2026;12(31). doi:<a href="https://doi.org/10.1126/sciadv.aed4451">10.1126/sciadv.aed4451</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1126/sciadv.aed4451 info:eu-repo/semantics/altIdentifier/e-issn/2375-2548 info:eu-repo/semantics/altIdentifier/pmid/42525771 info:eu-repo/semantics/openAccess