{"DOAJ_listed":"1","citation":{"chicago":"Lizée, Mathieu, Zhijia Zhang, Baptiste Coquinot, Qian Yang, and Lydéric Bocquet. “Architecting Mechanosensitive Nanofluidic Transport in Graphite Nanoslits.” <i>Science Advances</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/sciadv.aed4451\">https://doi.org/10.1126/sciadv.aed4451</a>.","apa":"Lizée, M., Zhang, Z., Coquinot, B., Yang, Q., &#38; Bocquet, L. (2026). Architecting mechanosensitive nanofluidic transport in graphite nanoslits. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.aed4451\">https://doi.org/10.1126/sciadv.aed4451</a>","ama":"Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. Architecting mechanosensitive nanofluidic transport in graphite nanoslits. <i>Science Advances</i>. 2026;12(31). doi:<a href=\"https://doi.org/10.1126/sciadv.aed4451\">10.1126/sciadv.aed4451</a>","mla":"Lizée, Mathieu, et al. “Architecting Mechanosensitive Nanofluidic Transport in Graphite Nanoslits.” <i>Science Advances</i>, vol. 12, no. 31, eaed4451, AAAS, 2026, doi:<a href=\"https://doi.org/10.1126/sciadv.aed4451\">10.1126/sciadv.aed4451</a>.","short":"M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, L. Bocquet, Science Advances 12 (2026).","ista":"Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. 2026. Architecting mechanosensitive nanofluidic transport in graphite nanoslits. Science Advances. 12(31), eaed4451.","ieee":"M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, and L. Bocquet, “Architecting mechanosensitive nanofluidic transport in graphite nanoslits,” <i>Science Advances</i>, vol. 12, no. 31. AAAS, 2026."},"license":"https://creativecommons.org/licenses/by/4.0/","PlanS_conform":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-09-24T12:00:31Z","supplementarymaterial":"yes","author":[{"last_name":"Lizée","first_name":"Mathieu","full_name":"Lizée, Mathieu"},{"last_name":"Zhang","first_name":"Zhijia","full_name":"Zhang, Zhijia"},{"last_name":"Coquinot","first_name":"Baptiste","id":"f8417bd4-f599-11ee-a482-b927e3ed1e8e","orcid":"0000-0001-5524-596X","full_name":"Coquinot, Baptiste"},{"full_name":"Yang, Qian","last_name":"Yang","first_name":"Qian"},{"first_name":"Lydéric","last_name":"Bocquet","full_name":"Bocquet, Lydéric"}],"date_created":"2026-09-17T11:05:47Z","status":"public","_id":"22952","title":"Architecting mechanosensitive nanofluidic transport in graphite nanoslits","abstract":[{"lang":"eng","text":"Mechanosensitive ion transport plays a central role in enabling living systems to perceive and adapt to their environment through the deformation of soft, embedded ion channels. In this work, we demonstrate that ion transport within a two-dimensional graphite nanoslit can be rationally engineered to achieve a bipolar, pressure-sensitive response without any structural deformation. The mechanosensitivity arises from the selective charging of one channel inlet, which acts as a reversible source of mobile charge carriers. These excess ions can then be advected in or out of the channel by the pressure-driven water flow, thereby modulating the ionic conductance. This mechanism is captured through a comprehensive electrohydrodynamic model that analytically accounts for coupled diffusion, convection, surface transport, diffusio-osmosis, and interfacial slippage, both inside and outside the nanoslit. The theoretical framework quantitatively reproduces the experimental data, showing that a simple surface charge pattern can give rise to complex, pressure-dependent conductance. These findings reveal how rich nonlinear couplings at the nanoscale can be harnessed to design adaptive, bioinspired nanofluidic systems, exemplified here by ionic pressure sensors."}],"article_type":"original","type":"journal_article","oa_version":"Published Version","OA_place":"publisher","OA_type":"gold","language":[{"iso":"eng"}],"issue":"31","scopus_import":"1","publication":"Science Advances","acknowledgement":"We acknowledge support from eRc project n-AQUA, grant agreement 101071937. B.c. acknowledges support from the nOMiS Foundation. M.L. acknowledges support from theAlexander von humboldt foundation. Q.Y. acknowledges support from the Royal SocietyUniversity Research Fellowship URF\\R1\\221096 and UK Research and innovation Grant (eP/X017575/1). ","publication_identifier":{"eissn":["2375-2548"]},"article_processing_charge":"Yes","file_date_updated":"2026-09-24T10:46:31Z","date_published":"2026-07-01T00:00:00Z","has_accepted_license":"1","fulldoi":"https://doi.org/10.1126/sciadv.aed4451","das_tickbox":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["530"],"intvolume":"        12","pmid":1,"year":"2026","quality_controlled":"1","publication_status":"published","article_number":"eaed4451","file":[{"success":1,"checksum":"ae3d6231ea5cea3a0014a6da2e8c8c30","date_created":"2026-09-24T10:46:31Z","access_level":"open_access","creator":"dernst","relation":"main_file","file_id":"22989","file_name":"2026_ScienceAdv_Lizee.pdf","content_type":"application/pdf","date_updated":"2026-09-24T10:46:31Z","file_size":1264180}],"researchdata_availability":"no","doi":"10.1126/sciadv.aed4451","volume":12,"oa":1,"dataavailabilitystatement":"All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. no new materials have been created for this work","day":"01","month":"07","department":[{"_id":"MiLe"}],"publisher":"AAAS","external_id":{"pmid":["42525771"]}}