article published yes Mathieu Lizée author Zhijia Zhang author Baptiste Coquinot author f8417bd4-f599-11ee-a482-b927e3ed1e8e0000-0001-5524-596X Qian Yang author Lydéric Bocquet author MiLe department Mechanosensitive ion transport plays a central role in enabling living systems to perceive and adapt to their environment through the deformation of soft, embedded ion channels. In this work, we demonstrate that ion transport within a two-dimensional graphite nanoslit can be rationally engineered to achieve a bipolar, pressure-sensitive response without any structural deformation. The mechanosensitivity arises from the selective charging of one channel inlet, which acts as a reversible source of mobile charge carriers. These excess ions can then be advected in or out of the channel by the pressure-driven water flow, thereby modulating the ionic conductance. This mechanism is captured through a comprehensive electrohydrodynamic model that analytically accounts for coupled diffusion, convection, surface transport, diffusio-osmosis, and interfacial slippage, both inside and outside the nanoslit. The theoretical framework quantitatively reproduces the experimental data, showing that a simple surface charge pattern can give rise to complex, pressure-dependent conductance. These findings reveal how rich nonlinear couplings at the nanoscale can be harnessed to design adaptive, bioinspired nanofluidic systems, exemplified here by ionic pressure sensors. https://research-explorer.ista.ac.at/download/22952/22989/2026_ScienceAdv_Lizee.pdf application/pdfno AAAS2026 eng 2375-2548 4252577110.1126/sciadv.aed4451 1231 Lizée, M., Zhang, Z., Coquinot, B., Yang, Q., &#38; Bocquet, L. (2026). Architecting mechanosensitive nanofluidic transport in graphite nanoslits. <i>Science Advances</i>. AAAS. <a href="https://doi.org/10.1126/sciadv.aed4451">https://doi.org/10.1126/sciadv.aed4451</a> Lizée, Mathieu, Zhijia Zhang, Baptiste Coquinot, Qian Yang, and Lydéric Bocquet. “Architecting Mechanosensitive Nanofluidic Transport in Graphite Nanoslits.” <i>Science Advances</i>. AAAS, 2026. <a href="https://doi.org/10.1126/sciadv.aed4451">https://doi.org/10.1126/sciadv.aed4451</a>. M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, and L. Bocquet, “Architecting mechanosensitive nanofluidic transport in graphite nanoslits,” <i>Science Advances</i>, vol. 12, no. 31. AAAS, 2026. Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. 2026. Architecting mechanosensitive nanofluidic transport in graphite nanoslits. Science Advances. 12(31), eaed4451. M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, L. Bocquet, Science Advances 12 (2026). Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. Architecting mechanosensitive nanofluidic transport in graphite nanoslits. <i>Science Advances</i>. 2026;12(31). doi:<a href="https://doi.org/10.1126/sciadv.aed4451">10.1126/sciadv.aed4451</a> Lizée, Mathieu, et al. “Architecting Mechanosensitive Nanofluidic Transport in Graphite Nanoslits.” <i>Science Advances</i>, vol. 12, no. 31, eaed4451, AAAS, 2026, doi:<a href="https://doi.org/10.1126/sciadv.aed4451">10.1126/sciadv.aed4451</a>. 229522026-09-17T11:05:47Z2026-09-24T12:00:31Z