---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22952'
abstract:
- lang: eng
  text: Mechanosensitive ion transport plays a central role in enabling living systems
    to perceive and adapt to their environment through the deformation of soft, embedded
    ion channels. In this work, we demonstrate that ion transport within a two-dimensional
    graphite nanoslit can be rationally engineered to achieve a bipolar, pressure-sensitive
    response without any structural deformation. The mechanosensitivity arises from
    the selective charging of one channel inlet, which acts as a reversible source
    of mobile charge carriers. These excess ions can then be advected in or out of
    the channel by the pressure-driven water flow, thereby modulating the ionic conductance.
    This mechanism is captured through a comprehensive electrohydrodynamic model that
    analytically accounts for coupled diffusion, convection, surface transport, diffusio-osmosis,
    and interfacial slippage, both inside and outside the nanoslit. The theoretical
    framework quantitatively reproduces the experimental data, showing that a simple
    surface charge pattern can give rise to complex, pressure-dependent conductance.
    These findings reveal how rich nonlinear couplings at the nanoscale can be harnessed
    to design adaptive, bioinspired nanofluidic systems, exemplified here by ionic
    pressure sensors.
acknowledgement: 'We acknowledge support from eRc project n-AQUA, grant agreement
  101071937. B.c. acknowledges support from the nOMiS Foundation. M.L. acknowledges
  support from theAlexander von humboldt foundation. Q.Y. acknowledges support from
  the Royal SocietyUniversity Research Fellowship URF\R1\221096 and UK Research and
  innovation Grant (eP/X017575/1). '
article_number: eaed4451
article_processing_charge: Yes
article_type: original
author:
- first_name: Mathieu
  full_name: Lizée, Mathieu
  last_name: Lizée
- first_name: Zhijia
  full_name: Zhang, Zhijia
  last_name: Zhang
- first_name: Baptiste
  full_name: Coquinot, Baptiste
  id: f8417bd4-f599-11ee-a482-b927e3ed1e8e
  last_name: Coquinot
  orcid: 0000-0001-5524-596X
- first_name: Qian
  full_name: Yang, Qian
  last_name: Yang
- first_name: Lydéric
  full_name: Bocquet, Lydéric
  last_name: Bocquet
citation:
  ama: Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. Architecting mechanosensitive
    nanofluidic transport in graphite nanoslits. <i>Science Advances</i>. 2026;12(31).
    doi:<a href="https://doi.org/10.1126/sciadv.aed4451">10.1126/sciadv.aed4451</a>
  apa: Lizée, M., Zhang, Z., Coquinot, B., Yang, Q., &#38; Bocquet, L. (2026). Architecting
    mechanosensitive nanofluidic transport in graphite nanoslits. <i>Science Advances</i>.
    AAAS. <a href="https://doi.org/10.1126/sciadv.aed4451">https://doi.org/10.1126/sciadv.aed4451</a>
  chicago: Lizée, Mathieu, Zhijia Zhang, Baptiste Coquinot, Qian Yang, and Lydéric
    Bocquet. “Architecting Mechanosensitive Nanofluidic Transport in Graphite Nanoslits.”
    <i>Science Advances</i>. AAAS, 2026. <a href="https://doi.org/10.1126/sciadv.aed4451">https://doi.org/10.1126/sciadv.aed4451</a>.
  ieee: M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, and L. Bocquet, “Architecting mechanosensitive
    nanofluidic transport in graphite nanoslits,” <i>Science Advances</i>, vol. 12,
    no. 31. AAAS, 2026.
  ista: Lizée M, Zhang Z, Coquinot B, Yang Q, Bocquet L. 2026. Architecting mechanosensitive
    nanofluidic transport in graphite nanoslits. Science Advances. 12(31), eaed4451.
  mla: Lizée, Mathieu, et al. “Architecting Mechanosensitive Nanofluidic Transport
    in Graphite Nanoslits.” <i>Science Advances</i>, vol. 12, no. 31, eaed4451, AAAS,
    2026, doi:<a href="https://doi.org/10.1126/sciadv.aed4451">10.1126/sciadv.aed4451</a>.
  short: M. Lizée, Z. Zhang, B. Coquinot, Q. Yang, L. Bocquet, Science Advances 12
    (2026).
das_tickbox: '1'
dataavailabilitystatement: All data needed to evaluate the conclusions in the paper
  are present in the paper and/or the Supplementary Materials. no new materials have
  been created for this work
date_created: 2026-09-17T11:05:47Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-09-24T12:00:31Z
day: '01'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1126/sciadv.aed4451
external_id:
  pmid:
  - '42525771'
file:
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  checksum: ae3d6231ea5cea3a0014a6da2e8c8c30
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  date_created: 2026-09-24T10:46:31Z
  date_updated: 2026-09-24T10:46:31Z
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file_date_updated: 2026-09-24T10:46:31Z
fulldoi: https://doi.org/10.1126/sciadv.aed4451
has_accepted_license: '1'
intvolume: '        12'
issue: '31'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Architecting mechanosensitive nanofluidic transport in graphite nanoslits
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...