---
res:
  bibo_abstract:
  - Tissue regeneration requires de novo patterning, which has been proposed to be
    facilitated by cellular heterogeneity. Yet how such heterogeneities are integrated
    with the mechanochemical state of the tissue and stabilized at the chromatin level
    into stable, spatially organized fates remains poorly understood. Using in vivo
    mouse intestinal regeneration models and organoids, we identify a critical density
    regime that produces a permissive window for heterogeneity in the mechanosensor
    Yes-associated protein 1 (YAP1). We show that YAP1 heterogeneity is coupled to
    lineage-biased chromatin accessibility and is decoded through FOXA1, which integrates
    the permissive chromatin state to Delta-Notch supracellular feedback and lineage
    commitment. This circuit generates fate bistability and preserves a memory of
    transient YAP1 activity, thereby maintaining spatial patterning as tissues return
    to homeostasis after injury. Together, our findings establish a multiscale framework
    in which tissue-scale mechanics tune single-cell competence and, through FOXA1-mediated
    bistability, convert transient heterogeneity into stable and self-organized tissue
    architecture.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Cornelia
      foaf_name: Schwayer, Cornelia
      foaf_surname: Schwayer
      foaf_workInfoHomepage: http://www.librecat.org/personId=3436488C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5130-2226
  - foaf_Person:
      foaf_givenName: Silvia
      foaf_name: Barbiero, Silvia
      foaf_surname: Barbiero
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Brückner, David
      foaf_surname: Brückner
      foaf_workInfoHomepage: http://www.librecat.org/personId=e1e86031-6537-11eb-953a-f7ab92be508d
    orcid: 0000-0001-7205-2975
  - foaf_Person:
      foaf_givenName: Koen C.
      foaf_name: Oost, Koen C.
      foaf_surname: Oost
  - foaf_Person:
      foaf_givenName: Clara
      foaf_name: Baader, Clara
      foaf_surname: Baader
  - foaf_Person:
      foaf_givenName: Nicole A.
      foaf_name: Repina, Nicole A.
      foaf_surname: Repina
  - foaf_Person:
      foaf_givenName: Jinse
      foaf_name: Kim, Jinse
      foaf_surname: Kim
  - foaf_Person:
      foaf_givenName: Oscar E.
      foaf_name: Diaz, Oscar E.
      foaf_surname: Diaz
  - foaf_Person:
      foaf_givenName: Isa
      foaf_name: Uccelli, Isa
      foaf_surname: Uccelli
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Capolupo, Laura
      foaf_surname: Capolupo
  - foaf_Person:
      foaf_givenName: Ludivine Challet
      foaf_name: Meylan, Ludivine Challet
      foaf_surname: Meylan
  - foaf_Person:
      foaf_givenName: Veronique
      foaf_name: Kalck, Veronique
      foaf_surname: Kalck
  - foaf_Person:
      foaf_givenName: Franziska
      foaf_name: Moos, Franziska
      foaf_surname: Moos
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Suppinger, Simon
      foaf_surname: Suppinger
  - foaf_Person:
      foaf_givenName: Qiutan
      foaf_name: Yang, Qiutan
      foaf_surname: Yang
  - foaf_Person:
      foaf_givenName: Jakob
      foaf_name: Schnabl, Jakob
      foaf_surname: Schnabl
  - foaf_Person:
      foaf_givenName: Umut
      foaf_name: Kilik, Umut
      foaf_surname: Kilik
  - foaf_Person:
      foaf_givenName: Matthieu
      foaf_name: Bourdon, Matthieu
      foaf_surname: Bourdon
  - foaf_Person:
      foaf_givenName: J. Gray
      foaf_name: Camp, J. Gray
      foaf_surname: Camp
  - foaf_Person:
      foaf_givenName: Brigitta
      foaf_name: Stockinger, Brigitta
      foaf_surname: Stockinger
  - foaf_Person:
      foaf_givenName: Alessandra
      foaf_name: Ferrari, Alessandra
      foaf_surname: Ferrari
  - foaf_Person:
      foaf_givenName: Marc
      foaf_name: Bühler, Marc
      foaf_surname: Bühler
  - foaf_Person:
      foaf_givenName: Michael B.
      foaf_name: Stadler, Michael B.
      foaf_surname: Stadler
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Prisca
      foaf_name: Liberali, Prisca
      foaf_surname: Liberali
  bibo_doi: 10.1016/j.cell.2026.06.009
  bibo_issue: '17'
  bibo_volume: 189
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0092-8674
  - http://id.crossref.org/issn/1097-4172
  dct_language: eng
  dct_publisher: Cell Press@
  dct_subject:
  - tissue patterning
  - heterogeneity
  - mechanics
  - intestinal regeneration
  - epigenetic competence
  - multiscale integration
  - modeling
  - organoids
  - image-based phenotyping
  - Yap1
  dct_title: Multiscale integration of tissue and chromatin context converts cell
    heterogeneity into stable intestinal patterning@
  fabio_hasPubmedId: '42379166'
...